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Fig. S1. Immunoreceptor tyrosine-based activation motif (ITAM)-truncated chimeric antigen receptors retain functional capacity in primary human T cells – T cells from three healthy donors were transduced with the indicated chimeric antigen receptors (CARs) and expanded in vitro. Transduced CD4+ and CD8+ cells, identified by FLAG expression, were assessed for CD107a mobilization and intracellular production of interferon (IFN)-γ, tumour necrosis factor (TNF)-α and interleukin (IL)-2 after stimulation for 6 h with the indicated concentrations of immobilized carcinoembryonic antigen (CEA) protein.

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