Fig. S1. Glycoconjugate administration schedule. Synthetic glycoconjugates were administered in two different administration schemes – presymptomatic (a) and symptomatic (b). The average onset of clinical symptoms was at day 24 ± 2·5 after immunization by type II collagen + complete Freund's adjuvant (CII+CFA). In the presymptomatic scheme, glycoconjugates (GCs) were administered at days 10, 13, 16, 23 and 30. In the symptomatic scheme, GCs were administered in the same time intervals starting from day 23 (first appearance of symptoms). Animals were killed at days 37 and 50 in presymptomatic and symptomatic schedules, respectively (in both cases 7 days after the last treatment dose).

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