Impact of suppressing retinoic acid-related orphan receptor gamma t (ROR)γt in ameliorating central nervous system autoimmunity
Version of Record online: 26 NOV 2014
© 2014 British Society for Immunology
Clinical & Experimental Immunology
Volume 179, Issue 1, pages 108–118, January 2015
How to Cite
Yang, Y., Winger, R. C., Lee, P. W., Nuro-Gyina, P. K., Minc, A., Larson, M., Liu, Y., Pei, W., Rieser, E., Racke, M. K. and Lovett-Racke, A. E. (2015), Impact of suppressing retinoic acid-related orphan receptor gamma t (ROR)γt in ameliorating central nervous system autoimmunity. Clinical & Experimental Immunology, 179: 108–118. doi: 10.1111/cei.12441
- Issue online: 26 NOV 2014
- Version of Record online: 26 NOV 2014
- Accepted manuscript online: 20 AUG 2014 10:00PM EST
- Manuscript Accepted: 15 AUG 2014
- National Institute of Health. Grant Number: R01 NS067441
- National Multiple Sclerosis Society. Grant Number: RG3812
- NIH Postbacculaureate Research Education Program (PREP). Grant Number: R25 GM089571
Fig. S1. Splenocytes from naive T cell receptor (TCR) Vα2·3/Vβ8·2 transgenic mice were transfected with siRNA-NS and siRNA-RORγt for 18 h. The cells were then activated with myelin basic protein (MBP) Ac1-11 for 3 days. RORγt expression and cytokine production [interleukin (IL)-17 and IFN-γ] was analysed by flow cytometry. Data are representative of multiple independent experiments.
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