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Prognostic significance of pituitary tumour-transforming gene-binding factor (PBF) expression in papillary thyroid carcinoma

Authors

  • Chuen Hsueh,

    Corresponding author
    1. Chang Gung Molecular Medicine Research Center and Graduate Institute of Basic Medical Sciences, Chang Gung University College of Medicine, Taoyuan, Taiwan
    • Department of Pathology, Chang Gung Memorial Hospital, Linko, Chang Gung University College of Medicine, Taoyuan, Taiwan
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  • Jen-Der Lin,

    1. Department of Internal Medicine, Chang Gung Memorial Hospital, Linko, Chang Gung University College of Medicine, Taoyuan, Taiwan
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  • Yu-Sun Chang,

    1. Chang Gung Molecular Medicine Research Center and Graduate Institute of Basic Medical Sciences, Chang Gung University College of Medicine, Taoyuan, Taiwan
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  • Swei Hsueh,

    1. Department of Pathology, Chang Gung Memorial Hospital, Linko, Chang Gung University College of Medicine, Taoyuan, Taiwan
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  • Tzu-Chieh Chao,

    1. Department of Surgery, Chang Gung Memorial Hospital, Linko, Chang Gung University College of Medicine, Taoyuan, Taiwan
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  • Jau-Song Yu,

    1. Chang Gung Molecular Medicine Research Center and Graduate Institute of Basic Medical Sciences, Chang Gung University College of Medicine, Taoyuan, Taiwan
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  • Shih-Ming Jung,

    1. Department of Pathology, Chang Gung Memorial Hospital, Linko, Chang Gung University College of Medicine, Taoyuan, Taiwan
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  • Ngan-Ming Tseng,

    1. Department of Radiation Oncology, Chang Gung Memorial Hospital, Linko, Chang Gung University College of Medicine, Taoyuan, Taiwan
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  • Jui-Hung Sun,

    1. Department of Internal Medicine, Chang Gung Memorial Hospital, Linko, Chang Gung University College of Medicine, Taoyuan, Taiwan
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  • Shau-Yun Kuo,

    1. Chang Gung Molecular Medicine Research Center and Graduate Institute of Basic Medical Sciences, Chang Gung University College of Medicine, Taoyuan, Taiwan
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  • Shir-Hwa Ueng

    1. Department of Pathology, Chang Gung Memorial Hospital, Linko, Chang Gung University College of Medicine, Taoyuan, Taiwan
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Correspondence: Chuen Hsueh, MD, Department of Pathology, Chang Gung Memorial Hospital, 5 Fu-Hsing Street, Kwei-Shan, Taoyuan 333, Taiwan. Tel.: +886 3 3281200 ext. 2741; Fax: +886 3 3280147; E-mail: ch9211@adm.cgmh.org.tw

Summary

Background

Pituitary tumour-transforming gene (PTTG)-binding factor (PBF), originally known as PTTG1 interacting protein (PTTG1IP), has been found to be significantly increased in well-differentiated thyroid cancer and independently associated with early tumour recurrence.

Objective

To assess the prognostic significance of PBF expression in a large cohort of papillary thyroid carcinoma (PTC) patients with a long-term follow-up.

Design and patients

Retrospective analysis of PBF expression in PTC cases at different stages and correlate it with various clinicopathological parameters and patient survival. Subjects included 153 patients who received a thyroid operation for PTC at Chang Gung Memorial Hospital between 1991 and 2000. All patients had a complete follow-up till the end of 2010.

Measurements

Immunohistochemical study for PBF expression on tissue sections from tumour specimens. Bond automated machine (Leica Microsystems, Germany) with a polyclonal rabbit anti-PBF antibody (LifeSpan BioSciences, LS-C118942, Seattle, WA, USA) was used. SPSS 13.0 for Windows (SPSS Inc, Chicago, IL, USA) was used for all statistical analyses.

Results

High PBF expression was significantly correlated with age (= 0·0298), distant metastases at diagnosis (= 0·0139), tumour multicentricity (= 0·0035), TNM stage (= 0·0103), locoregional recurrence (= 0·0410) and disease-specific mortality (= 0·0064). The expression level of PBF was significantly correlated with disease-specific survival (= 0·0065). Cox regression analysis showed that age, tumour size and PBF expression were independent prognostic indicators (= 0·0097, = 0·0021 and = 0·0179).

Conclusion

PBF expression may be a promising biomarker for prognostic and therapeutic purpose. More large-scale studies are needed to clarify its potential usefulness.

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