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Clinical Endocrinology

A lower value for quantitative ultrasound at radius is an additional indicator of metabolic syndrome and cardiovascular disease risk

Authors

  • Bei Tao,

    1. Department of Endocrine and Metabolic Disease, Rui-jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Endocrine and Metabolic Division of E-Institutes of Shanghai Universities (EISU), Shanghai, China
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  • Zhen Li,

    1. Department of Endocrine and Metabolic Disease, Rui-jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Endocrine and Metabolic Division of E-Institutes of Shanghai Universities (EISU), Shanghai, China
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  • Hong-Yan Zhao,

    1. Department of Endocrine and Metabolic Disease, Rui-jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Endocrine and Metabolic Division of E-Institutes of Shanghai Universities (EISU), Shanghai, China
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  • Li-Hao Sun,

    1. Department of Endocrine and Metabolic Disease, Rui-jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Endocrine and Metabolic Division of E-Institutes of Shanghai Universities (EISU), Shanghai, China
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  • Lin Zhao,

    1. Department of Endocrine and Metabolic Disease, Rui-jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Endocrine and Metabolic Division of E-Institutes of Shanghai Universities (EISU), Shanghai, China
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  • Xiao-Ying Li,

    1. Department of Endocrine and Metabolic Disease, Rui-jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Endocrine and Metabolic Division of E-Institutes of Shanghai Universities (EISU), Shanghai, China
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  • Wei-Qing Wang,

    1. Department of Endocrine and Metabolic Disease, Rui-jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Endocrine and Metabolic Division of E-Institutes of Shanghai Universities (EISU), Shanghai, China
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  • Guang Ning,

    1. Department of Endocrine and Metabolic Disease, Rui-jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Endocrine and Metabolic Division of E-Institutes of Shanghai Universities (EISU), Shanghai, China
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  • Jian-Min Liu

    Corresponding author
    • Department of Endocrine and Metabolic Disease, Rui-jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Endocrine and Metabolic Division of E-Institutes of Shanghai Universities (EISU), Shanghai, China
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Correspondence: Jian-Min Liu, Department of Endocrine and Metabolic Disease, Rui-jin Hospital, Shanghai Jiao-Tong University School of Medicine. 197 Ruijin Er Road, Shanghai 200025, China. Fax: 0086 21 64373514; Tel.: 0086 21 64370045, ext: 665342; E-mail: ljmhh@sh163.net

Summary

Background

The relationships between quantitative ultrasound (QUS) values, metabolic syndrome (MetS) and cardiovascular disease (CVD) risk are unclear.

Objective The objective was to determine the relationships between QUS and MetS as well as CVD risk.

Design

This was a cross-sectional study conducted in Shanghai, China.

Patients

One-thousand four hundred and thirty-nine Chinese women and men with or without MetS were studied.

Measurements

Speed of sound (SOS) at radius, phalanx and tibia and their relationships with MetS and Framingham's 10-year cardiovascular disease risk scores were investigated.

Results

Premenopausal women with MetS had significant lower SOS at radius than those without MetS after adjusting for age, BMI and fat mass percentage (P = 0·02). The radius SOS was negatively associated with waist circumference (r = −0·109, P = 0·025), waist-to-hip ratio (r = −0·124, P = 0·01) and 2 h postprandial glucose level (r = −0·125, P = 0·012) in premenopausal women. Waist circumference, waist-to-hip ratio and 2 h postprandial glucose level increased with the decreasing tertiles of radius SOS after adjustment of age (P = 0·003, 0·002 and 0·008, respectively). The CVD risk increased with decreasing tertiles of radius SOS in postmenopausal women even after the adjustment of age, years since menopause, MetS components, smoking and alcohol habits (P < 0·001), but not in premenopausal women and men.

Conclusions

Lower radius SOS is associated with greater risks of MetS and CVD in premenopausal and postmenopausal women, respectively. The QUS value derived from non-weight-bearing site, such as radius, may represent an additional indicator of MetS and CVD risk in women.

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