Clinical Endocrinology

Relation between lipoprotein subfractions and TSH levels in the cardiovascular risk among women with subclinical hypothyroidism

Authors

  • A. Hernández-Mijares,

    1. Service of Endocrinology, University Hospital Dr. Peset, Valencia, Spain
    2. Department of Medicine, Faculty of Medicine, University of Valencia, Valencia, Spain
    3. Foundation for the Promotion of Healthcare and Biomedical Research in the Valencian Community (FISABIO), Valencia, Spain
    4. Institute of Health Research INCLIVA, Valencia, Spain
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  • A. Jover,

    1. Service of Endocrinology, University Hospital Dr. Peset, Valencia, Spain
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  • L. Bellod,

    1. Service of Endocrinology, University Hospital Dr. Peset, Valencia, Spain
    2. Foundation for the Promotion of Healthcare and Biomedical Research in the Valencian Community (FISABIO), Valencia, Spain
    3. Institute of Health Research INCLIVA, Valencia, Spain
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  • C. Bañuls,

    1. Service of Endocrinology, University Hospital Dr. Peset, Valencia, Spain
    2. Department of Medicine, Faculty of Medicine, University of Valencia, Valencia, Spain
    3. Institute of Health Research INCLIVA, Valencia, Spain
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  • E. Solá,

    1. Service of Endocrinology, University Hospital Dr. Peset, Valencia, Spain
    2. Institute of Health Research INCLIVA, Valencia, Spain
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  • S. Veses,

    1. Service of Endocrinology, University Hospital Dr. Peset, Valencia, Spain
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  • V. M. Víctor,

    1. Service of Endocrinology, University Hospital Dr. Peset, Valencia, Spain
    2. Foundation for the Promotion of Healthcare and Biomedical Research in the Valencian Community (FISABIO), Valencia, Spain
    3. Institute of Health Research INCLIVA, Valencia, Spain
    4. CIBER CB06/04/0071 research group, CIBER Hepatic and Digestive Diseases, University of Valencia, Valencia, Spain
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  • M. Rocha

    Corresponding author
    1. Foundation for the Promotion of Healthcare and Biomedical Research in the Valencian Community (FISABIO), Valencia, Spain
    2. Institute of Health Research INCLIVA, Valencia, Spain
    3. CIBER CB06/04/0071 research group, CIBER Hepatic and Digestive Diseases, University of Valencia, Valencia, Spain
    • Service of Endocrinology, University Hospital Dr. Peset, Valencia, Spain
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Correspondence: Milagros Rocha, Service of Endocrinology, University Hospital Dr. Peset, Av. Gaspar Aguilar 90, 46017 Valencia, Spain. Tel.: (+34) 961622492; Fax: (+34) 961622492; E-mail: milagros.rocha@uv.es

Summary

Objective

Subclinical hypothyroidism (SCH) is a common condition associated with increased cardiovascular risk. A standard treatment is yet to be established, as there is no consensus on the TSH cut-off values which should be used as indicators. Thus, the aim of this study was to assess cardiovascular risk in patients with SCH and to differentiate it according to TSH levels.

Design

This was an observational study conducted in an academic medical centre.

Patients

The study population consisted of 95 middle-aged women recently diagnosed with SCH and 65 euthyroid controls.

Measurements

We measured anthropometric parameters, lipid cardiovascular risk markers and lipoprotein subclasses of HDL and LDL.

Results

Patients with SCH exhibited a significant increase in triglycerides and atherogenic index of plasma and a significant reduction in HDL-cholesterol with respect to the control group after adjusted by age and BMI. A similar lipid profile was observed in both SCH groups. However, patients with TSH levels higher than 10 mIU/l showed a significant reduction in LDL particle size, which was associated with a higher prevalence of atherogenic pattern B.

Conclusions

Our findings indicate that cardiovascular risk is affected in patients with TSH levels over 10 mIU/l, who have a lipid profile characteristic of atherogenic dyslipidemia.

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