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Circulating interleukin 6 and soluble forms of its receptors in relation to resting energy expenditure in women with anorexia nervosa

Authors

  • Monika Karczewska-Kupczewska,

    Corresponding author
    1. Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Bialystok
    • Correspondence: Monika Karczewska-Kupczewska, Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, M.C. Sklodowskiej 24a, 15-276 Bialystok, Poland. Tel.: +48 85 7468239; Fax: +48 85 7447611; E-mail: monika3101@wp.pl

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  • Agnieszka Adamska,

    1. Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Bialystok
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  • Agnieszka Nikołajuk,

    1. Department of Prophylaxis of Metabolic Diseases, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn, Poland
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  • Elżbieta Otziomek,

    1. Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Bialystok
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  • Maria Górska,

    1. Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Bialystok
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  • Irina Kowalska,

    1. Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Bialystok
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  • Marek Strączkowski

    1. Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Bialystok
    2. Department of Prophylaxis of Metabolic Diseases, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn, Poland
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Abstract

Context

Anorexia nervosa (AN) is an eating disorder, resulting in sustained low weight and marked decrease in fat mass. Interleukin 6 (IL-6) may play a role in appetite, energy expenditure and body weight control. IL-6 acts through binding with membrane receptor (IL-6R) and activates glycoprotein 130 (gp130) signalling. Both IL-6R and gp130 are present in the blood in the soluble forms (sIL-6R and sgp130 respectively). sIL-6R sensitizes cells towards IL-6, whereas sgp130 inhibits gp130 signalling.

Objective

To estimate circulating IL-6/sIL-6R/sgp130 system and its relationships with body weight and resting energy expenditure (REE) in AN women.

Patients

We examined 19 women with AN and 27 healthy normal-weight female controls.

Measurements

Indirect calorimetry and the measurement of serum IL-6, sIL-6R and sgp130 concentrations were performed in all the subjects.

Results

REE was decreased in AN women (P < 0·001). Serum IL-6 was higher in AN women in comparison with control group (P = 0·005). Serum sIL-6R was lower (P = 0·009) and serum sgp130 was higher (P = 0·004) in AN women in comparison with controls. IL-6 and sIL-6R were related to REE in the entire study population (r = −0·54, P < 0·001 and r = 0·48, P = 0·001 respectively) and in AN group (r = −0·54, P = 0·024 and r = 0·60, P = 0·011 respectively).

Conclusions

Increased IL-6 in AN seems to be compensated by the changes in sIL-6R and sgp130, which are directed towards inhibition of IL-6 action. The balance between these factors might play a role in the regulation of energy expenditure in AN.

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