Serum FGF21 concentration is associated with hypertriglyceridaemia, hyperinsulinaemia and pericardial fat accumulation, independently of obesity, but not with current coronary artery status
Article first published online: 6 MAY 2013
© 2012 John Wiley & Sons Ltd
Volume 80, Issue 1, pages 57–64, January 2014
How to Cite
Lee, Y., Lim, S., Hong, E.-S., Kim, J. H., Moon, M. K., Chun, E. J., Choi, S. I., Kim, Y.-B., Park, Y. J., Park, K. S., Jang, H. C. and Choi, S. H. (2014), Serum FGF21 concentration is associated with hypertriglyceridaemia, hyperinsulinaemia and pericardial fat accumulation, independently of obesity, but not with current coronary artery status. Clinical Endocrinology, 80: 57–64. doi: 10.1111/cen.12134
- Issue published online: 5 DEC 2013
- Article first published online: 6 MAY 2013
- Accepted manuscript online: 19 DEC 2012 11:31PM EST
- Manuscript Accepted: 14 DEC 2012
- Manuscript Revised: 22 NOV 2012
- Manuscript Revised: 11 NOV 2012
- Manuscript Received: 22 AUG 2012
- National Project for Personalized Genomic Medicine. Grant Number: A111218-CP02
- Seoul National University Bundang Hospital. Grant Number: 2005
Fibroblast growth factor 21 (FGF21) is an emerging metabolic regulator associated with glucose and lipid metabolism. However, previous studies of FGF21 have been largely confounded by obesity, and data are limited for advanced outcomes such as coronary artery disease (CAD) and ectopic fat accumulation. We investigated the associations between serum FGF21 concentrations and glucose/lipid metabolism, CAD, and pericardial fat deposition in subjects strictly matched for obesity parameters.
Design, Patients and Measurements
We enrolled 189 patients who had undergone cardiac multidetector coronary computed tomography. We measured cardiometabolic parameters and serum FGF21 levels within body mass index (BMI)-matched groups. Correlations and linear regressions were analysed among serum FGF21 levels, pericardial fat volumes and cardiometabolic parameters. Serum FGF21 concentrations were compared in patients with and without diabetes, metabolic syndrome (MS) or CAD.
Serum FGF21 concentrations were significantly higher in BMI-matched patients with MS (107·2 ± 83·6 vs 82·1 ± 67·4 ng/l without MS, P < 0·05), but not among those with diabetes (84·3 ± 56·4 vs 96·3 ± 98·9 ng/l without diabetes, P = 0·300) or CAD (89·6 ± 65·8 vs 84·2 ± 83·1 ng/l without CAD, P = 0·633). Serum FGF21 concentrations correlated positively with triglycerides, low-density lipoprotein–cholesterol, insulin, HOMA-IR and pericardial fat volume. They showed an independent association with pericardial fat volume (β = 0·111 ± 0·053, P < 0·05).
Serum FGF21 concentrations were significantly associated with lipid profiles, insulin resistance, pericardial fat volume and MS, independently of obesity, but not with overt CAD or diabetes.