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Live birth rates following in vitro fertilization in women with thyroid autoimmunity and/or subclinical hypothyroidism

Authors

  • Joyce Chai,

    Corresponding author
    1. Department of Obstetrics and Gynaecology, University of Hong Kong, Hong Kong Special Administration Region, China
    • Correspondence: Joyce Chai, Department of Obstetrics and Gynaecology, Queen Mary Hospital, 6/F., Professorial Block, 102 Pokfulam Road, Hong Kong, China. Tel.: +852 22554684; Fax: +852 25173218; E-mail: jchai@hkucc.hku.hk

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  • Wing-Yee T. Yeung,

    1. Department of Obstetrics and Gynaecology, University of Hong Kong, Hong Kong Special Administration Region, China
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  • Chi-Yan V. Lee,

    1. Department of Obstetrics and Gynaecology, University of Hong Kong, Hong Kong Special Administration Region, China
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  • Hang-Wun R. Li,

    1. Department of Obstetrics and Gynaecology, University of Hong Kong, Hong Kong Special Administration Region, China
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  • Pak-Chung Ho,

    1. Department of Obstetrics and Gynaecology, University of Hong Kong, Hong Kong Special Administration Region, China
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  • Hung-Yu E. Ng

    1. Department of Obstetrics and Gynaecology, University of Hong Kong, Hong Kong Special Administration Region, China
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Summary

Objective

To investigate whether the live birth rate following in vitro fertilization (IVF) is affected by thyroid autoimmunity (TAI) and/or subclinical hypothyroidism in subfertile women.

Design and setting

Retrospective study in a university infertility clinic.

Patients

A total of 627 women without past or current history of thyroid disorder undergoing their first IVF cycle.

Intervention

Pre-IVF archived blood serum samples were tested for TAI and thyroid function tests.

Main outcome measure

Live birth rate.

Results

The clinical pregnancy rate, live birth rate and miscarriage rate were similar among women with or without TAI and/or subclinical hypothyroidism using a TSH threshold 4·5 mIU/l. Thyroid autoantibody level did not affect these IVF outcomes.

Conclusion

The live birth rate and miscarriage rate of women with TAI and/or subclinical hypothyroidism following IVF were not impaired.

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