Get access

Association between thyroid hormones and body fat in euthyroid subjects

Authors

  • Ruizhen Ren,

    1. Department of Endocrinology, Provincial Hospital Affiliated to Shandong University, Jinan, China
    2. Department of Endocrinology, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai, China
    Search for more papers by this author
  • Xiuyun Jiang,

    1. Department of Endocrinology, Provincial Hospital Affiliated to Shandong University, Jinan, China
    2. Institute of Endocrinology, Shandong Academy of Clinical Medicine, Jinan, China
    Search for more papers by this author
  • Xu Zhang,

    1. Department of Endocrinology, Provincial Hospital Affiliated to Shandong University, Jinan, China
    2. Institute of Endocrinology, Shandong Academy of Clinical Medicine, Jinan, China
    Search for more papers by this author
  • Qingbo Guan,

    1. Department of Endocrinology, Provincial Hospital Affiliated to Shandong University, Jinan, China
    2. Institute of Endocrinology, Shandong Academy of Clinical Medicine, Jinan, China
    Search for more papers by this author
  • Chunxiao Yu,

    1. Department of Endocrinology, Provincial Hospital Affiliated to Shandong University, Jinan, China
    2. Institute of Endocrinology, Shandong Academy of Clinical Medicine, Jinan, China
    Search for more papers by this author
  • Youzhang Li,

    1. Network information center, Provincial Hospital Affiliated to Shandong University, Jinan, China
    Search for more papers by this author
  • Ling Gao,

    1. Central laboratory, Provincial Hospital Affiliated to Shandong University, Jinan, China
    Search for more papers by this author
  • Haiqing Zhang,

    Corresponding author
    1. Department of Endocrinology, Provincial Hospital Affiliated to Shandong University, Jinan, China
    2. Department of Endocrinology, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai, China
    • Correspondence: Jiajun Zhao and Haiqing Zhang, Department of Endocrinology, Provincial Hospital Affiliated to Shandong University, 324, Jing 5 Road, Jinan 250021, Shandong, China. Tel.: +86 531 85186910; Fax: +86 531 87037758; E-mails: jjzhao@medmail.com.cn and haiqingzhang7576@163.com

    Search for more papers by this author
  • Jiajun Zhao

    Corresponding author
    1. Department of Endocrinology, Provincial Hospital Affiliated to Shandong University, Jinan, China
    2. Department of Endocrinology, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai, China
    • Correspondence: Jiajun Zhao and Haiqing Zhang, Department of Endocrinology, Provincial Hospital Affiliated to Shandong University, 324, Jing 5 Road, Jinan 250021, Shandong, China. Tel.: +86 531 85186910; Fax: +86 531 87037758; E-mails: jjzhao@medmail.com.cn and haiqingzhang7576@163.com

    Search for more papers by this author

Summary

Objective

Thyroid hormones disorders are associated with changes of body composition. However, the relationship between thyroid hormones and body fat in a euthyroid population is unclear. The aim of this study was to explore the association between thyroid hormones and body fat in a euthyriod population.

Subjects

A total of 865 euthyroid individuals were recruited in this study. Subjects with thyroid diseases or diabetes and who were taking medications that could influence thyroid hormones, weight or glucose metabolism were excluded.

Measurements

FT3, FT4, lipid parameters, fasting insulin (FINS) and blood glucose were determined, and homeostasis model assessment for insulin resistance (HOMA-IR) was calculated. Anthropometric measurements were taken, and body fat parameters were assessed.

Results

Serum FT3 was slightly higher in body mass index (BMI) ≥25 kg/m2 group than that in BMI <25 kg/m2 group (P < 0·05). However, the difference was too small to have clinical significance. FT4 levels were not significantly different between the two groups. Body weight, BMI, waist circumference, hip circumference, waist-to-hip ratio (WHR), percentage of body fat (PBF), waist-fat-to-hip-fat ratio, FINS and HOMA-IR increased linearly with the elevation of FT3 adjusted for age and gender. A multivariate linear regression analysis revealed that fat mass, PBF, HOMA-IR and FT4 contributed significantly to FT3 levels.

Conclusion

Grouped according to BMI, overweight and obese subjects have similar thyroid hormones compared to those with normal weight. Body composition parameters increase with the elevation of FT3, and FT3 is associated with body fat parameters in euthyroid subjects.

Get access to the full text of this article

Ancillary