Competing/conflicts of interest: No stated conflict of interest.
Prospective longitudinal study of corneal collagen cross-linking in progressive keratoconus
Version of Record online: 14 DEC 2012
© 2012 The Authors. Clinical and Experimental Ophthalmology © 2012 Royal Australian and New Zealand College of Ophthalmologists
Clinical & Experimental Ophthalmology
Volume 41, Issue 6, pages 531–536, August 2013
How to Cite
Viswanathan, D. and Males, J. (2013), Prospective longitudinal study of corneal collagen cross-linking in progressive keratoconus. Clinical & Experimental Ophthalmology, 41: 531–536. doi: 10.1111/ceo.12035
Funding sources: No stated funding sources.
- Issue online: 31 JUL 2013
- Version of Record online: 14 DEC 2012
- Accepted manuscript online: 13 NOV 2012 03:39AM EST
- Manuscript Accepted: 31 OCT 2012
- Manuscript Received: 19 JUN 2012
- collagen cross-linking;
- maximum keratometry
Collagen cross-linking has been reported to be effective in treating progressive keratoconus, and this study aims to evaluate the long-term efficacy of this procedure.
Prospective longitudinal interventional study of patients with progressive keratoconus who underwent cross-linking in a tertiary referral hospital.
Thirty-five patients (51 eyes) who underwent cross-linking with a mean follow-up of 14.38 ± 9.36 months (range 6–48) were compared with a control group of 25 fellow eyes that did not undergo the procedure.
Cross-linking was performed using 0.1% riboflavin (in 20% dextran T500) and ultraviolet A irradiation (370 nm, 3 mW/cm2, 30 min).
Main Outcome Measures
Maximum keratometry in dioptres, logMAR best spectacle-corrected visual acuity, cylindrical power, manifest refraction spherical equivalent and central corneal thickness.
Analysis of the treated group demonstrated a significant flattening of maximum keratometry by 0.96 ± 2.33 dioptres (P = 0.005) and a significant improvement in visual acuity by 0.05 ± 0.13 logMAR (P = 0.04). In the control group, maximum keratometry increased significantly by 0.43 ± 0.85 dioptres (P = 0.05), and visual acuity decreased by mean 0.05 ± 0.14 (P = 0.2). No statistical differences were noted regarding cylindrical power, spherical equivalent or corneal thickness in both groups.
Results indicate that corneal collagen cross-linking using riboflavin and ultraviolet A is effective as a therapeutic option in cases of progressive keratoconus by reducing the corneal curvature and by improving the visual acuity in these patients.