Competing/conflicts of interest: No stated conflict of interest.
Twin studies in inherited eye disease
Article first published online: 4 DEC 2013
© 2013 Royal Australian and New Zealand College of Ophthalmologists
Clinical & Experimental Ophthalmology
Volume 42, Issue 1, pages 84–93, January/February 2014
How to Cite
Nag, A. and Hammond, C. J. (2014), Twin studies in inherited eye disease. Clinical & Experimental Ophthalmology, 42: 84–93. doi: 10.1111/ceo.12233
Funding sources: No stated funding sources.
- Issue published online: 17 JAN 2014
- Article first published online: 4 DEC 2013
- Accepted manuscript online: 30 SEP 2013 09:14AM EST
- Manuscript Accepted: 17 JUL 2013
- Manuscript Received: 18 FEB 2013
- Fight for Sight
- Worshipful Company of Spectacle Makers
- Wellcome Trust
- National Institute for Health Research (NIHR) Clinical Research Facility at Guy's & St Thomas' NHS Foundation Trust
- NIHR Biomedical Research Centre based at Guy's and St Thomas' NHS Foundation Trust
- King's College London
- eye disease;
- twin study
Eye diseases represent a significant source of health impairment in humans. Twin studies offer an excellent model to dissect the genetic basis of human diseases. In this review, we discuss the potential advantages of using twin-based studies in investigating the genetics of eye diseases – from heritability estimation to identifying underlying genetic and epigenetic changes. We also discuss some of the notable findings of twin studies exploring the genetics of eye diseases. Finally, we suggest other novel approaches that can be utilized to tap the potential of twin studies to provide a more complete understanding of genetic factors underlying ocular diseases.