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Chromosome 9p21 primary open-angle glaucoma susceptibility locus: a review

Authors

  • Soo Khai Ng MBBS,

    Corresponding author
    1. South Australian Institute of Ophthalmology, Royal Adelaide Hospital, Adelaide, South Australia, Australia
    2. University of Adelaide, Adelaide, South Australia, Australia
    • Correspondence: Dr Soo Khai Ng, South Australian Institute of Ophthalmology, Adelaide, SA 5000, Australia. Email: soo.ng8098@gmail.com

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  • Robert J Casson DPhil FRANZCO,

    1. South Australian Institute of Ophthalmology, Royal Adelaide Hospital, Adelaide, South Australia, Australia
    2. University of Adelaide, Adelaide, South Australia, Australia
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  • Kathryn P Burdon PhD,

    1. Department of Ophthalmology, Flinders University, Flinders Medical Centre, Adelaide, South Australia, Australia
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  • Jamie E Craig DPhil FRANZCO

    1. Department of Ophthalmology, Flinders University, Flinders Medical Centre, Adelaide, South Australia, Australia
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  • Competing/conflicts of interest: No stated conflict of interest.
  • Funding sources: No stated funding sources.

Abstract

Primary open-angle glaucoma (POAG) is a genetically complex disease. Genome-wide association study (GWAS) is a particularly useful tool in the search for genetic contributions to glaucoma. Recently, chromosome 9p21 has become a major focus of research endeavour, with multiple genome-wide association studies suggesting associations to POAG. Herein, we provide a review of the chromosome 9p21 susceptibility locus as a risk factor for POAG.

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