Antivascular endothelial growth factors in the treatment of macular oedema secondary to central retinal vein occlusion: a meta-analysis

Authors

  • Shuangwen Zhou MD BS,

    1. Department of Ophthalmology, Shanghai First People's Hospital, Shanghai Jiaotong University, Shanghai, China
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  • Jianping Gao BS,

    1. Department of Nutrition, School of Medicine, Shanghai Jiaotong University, Shanghai, China
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  • Xun Xu MD MS

    Corresponding author
    1. Department of Ophthalmology, Shanghai First People's Hospital, Shanghai Jiaotong University, Shanghai, China
    • Correspondence: Dr Xun Xu, Department of Ophthalmology, Shanghai First People's Hospital, Shanghai Jiaotong University, 100 Haining Road, Shanghai 200080, China. Email: drxuxun@sjtu.edu.cn

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  • Competing/conflicts of interest: No stated conflict of interest.
  • Funding sources: This work was funded by the National Science and Technology Major Projects of the Twelfth Five-year Plan (No. 2011ZX09302-007-02), the National Natural Science Foundation of China (No. 81273424), the National Natural Science Foundation of China (No. 81170862) and Shanghai Key Laboratory of Ocular Fundus Diseases. The funders had no role in the study design, data collection and analysis, the decision to publish, or preparation of the manuscript.

Abstract

Background

Macular oedema secondary to central retinal vein occlusion is a major cause of vision loss. Intraocuclar anti-vascular endothelial growth factor injection is a promising treatment but lacks clinical evidence of its safety and efficacy.

Design

Meta-analysis.

Participants

Patients from previously reported randomized, controlled trials comparing intravitreal anti-vascular endothelial growth factor versus sham injections.

Methods

A comprehensive search in MEDLINE, CENTRAL, and EMBASE was conducted for reports published by April 2013. A meta-analysis of the retrieved data was conducted in RevMan 5.2 software.

Main Outcome Measures

Primary outcome measures were changes in best-corrected visual acuity and central retinal thickness from baseline. Secondary outcome measures were the proportion of eyes changing 15 or more letters on the Early Treatment in Diabetic Retinopathy Study chart, the proportion with neovascularization and changes in the 25-item Visual Function Questionnaire. Severe adverse events were summarized to assess safety.

Results

Six trials involving a total of 940 eyes were included in the meta-analysis. The mean difference in 6-month changes in best-corrected visual acuity and central retinal thickness for the anti-vascular endothelial growth factor group were 15.2 Early Treatment Diabetic Retinopathy Study letters (P < 0.00001) and −242.2 μm (P < 0.00001), respectively. Severe adverse event incidence was similar between the groups.

Conclusions

Intravitreal anti-vascular endothelial growth factor injections were safe and effective for macular oedema secondary to central retinal vein occlusion. The efficacy was rapid and robust. Further trials are needed to determine the detailed indications and therapeutic regimens of anti-vascular endothelial growth factor treatments.

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