Albert Wu and Michelle T Sun contributed equally.
Histological subtypes of periocular basal cell carcinoma
Article first published online: 11 MAR 2014
© 2014 Royal Australian and New Zealand College of Ophthalmologists
Clinical & Experimental Ophthalmology
Volume 42, Issue 7, pages 603–607, September/October 2014
How to Cite
Wu, A., Sun, M. T., Huilgol, S. C., Madge, S. and Selva, D. (2014), Histological subtypes of periocular basal cell carcinoma. Clinical & Experimental Ophthalmology, 42: 603–607. doi: 10.1111/ceo.12298
Competing/conflicts of interest: No stated conflict of interest.
Funding sources: No stated funding sources.
- Issue published online: 11 OCT 2014
- Article first published online: 11 MAR 2014
- Accepted manuscript online: 17 FEB 2014 09:48PM EST
- Manuscript Accepted: 16 JAN 2014
- Manuscript Received: 11 SEP 2013
- basal cell carcinoma;
To determine the proportion of different subtypes of periocular BCC in South Australia.
One thousand seven hundred thirteen consecutive periocular basal cell carcinoma (BCC) excision specimens.
Histological analysis of consecutive periocular BCC specimens.
Main Outcome Measures
Date of resection, patient age at resection, gender, tumour location, histological subtype and perineural invasion.
From 2006 to 2012, a total of 1713 consecutive periocular BCC excision specimens were analysed. The mean age at resection was 68.8 years (median: 71, range: 21–101). Most specimens (56.4%) were removed from male patients. 52.7% involved the lower eyelid, 29.0% the medial canthus, 10.9% the lateral canthus and 7.5% the upper eyelid. The main histological subtypes identified were nodular (65.7%), infiltrative (17.5%), superficial (12.6%) and micronodular (4.2%). Of the specimens, 25.6% had more than one subtype. The most common subtype combinations were nodular with infiltrative (49.7%), and nodular with superficial (26.0%).
The majority of periocular BCC were located on the lower lid and classified histologically as nodular. Infiltrative BCC occurred more frequently than the superficial subtype. As the proportion of mixed BCC containing aggressive subtypes is high, surgical excision with margin control should be considered for periocular BCC.