These authors contributed equally to this work.
Association of HLA locus variant in Parkinson's disease
Article first published online: 29 OCT 2012
© 2012 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Special Issue: Variant
Volume 84, Issue 5, pages 501–504, November 2013
How to Cite
Association of HLA locus variant in Parkinson's disease., , , , , , , , , , , , , .
The authors have no conflict of interest to declare.
- Issue published online: 17 OCT 2013
- Article first published online: 29 OCT 2012
- Accepted manuscript online: 20 OCT 2012 07:05AM EST
- Manuscript Revised: 17 SEP 2012
- Manuscript Accepted: 17 SEP 2012
- Manuscript Received: 8 JUL 2012
- National Medical Research Council
- Singapore Millennium Foundation
- Duke Graduate Medical School
- The University of Malaya. Grant Number: E000033 HIR-MOHE
- Parkinson's disease;
A variant (rs3129882) in the genome-wide association study (GWAS)-linked variant [in the human leukocyte antigen (HLA) gene region] has been reported to associate with an increased risk of Parkinson's disease (PD) in Caucasian population. Studies among Chinese are limited. To address this, we analysed rs3129882 in a total of 1312 subjects of Chinese ethnicity from independent Asian centers comprising of 675 controls and 637 PD cases. The rs3129882 variant was associated with a decreased risk in our ethnic Chinese PD patients. Logistic regression analysis taking into consideration variables of age, gender and race showed that allele A reduced the risk of PD via a dominant model [odds ratio (OR) = 0.77, 95% confidence interval (CI) = 0.62, 0.96, p = 0.018]. As HLA is a highly polymorphic region, it is possible that ethnic-specific effect or environmental agents may modulate the effect of this GWAS-linked locus in influencing the risk of PD.