The authors report no conflicts of interest.
Epigenetic changes in diabetes
Article first published online: 11 MAR 2013
© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Volume 84, Issue 1, pages 1–10, July 2013
How to Cite
Epigenetic changes in diabetes., .
- Issue published online: 9 JUN 2013
- Article first published online: 11 MAR 2013
- Accepted manuscript online: 9 FEB 2013 06:56AM EST
- Manuscript Revised: 5 FEB 2013
- Manuscript Accepted: 5 FEB 2013
- Manuscript Received: 9 JAN 2013
- Juvenile Diabetes Research Foundation International (JDRF)
- Diabetes Australia Research Trust (DART)
- National Health and Medical Research Council (NHMRC)
- Australian Postgraduate Award (APA)
- National Heart Foundation of Australia (NHF)
- metabolic memory;
Diabetes is a multifactorial disease with numerous pathways influencing its progression and recent observations suggest that the complexity of the disease cannot be entirely accounted for by genetic predisposition. A compelling argument for an epigenetic component is rapidly emerging. Epigenetic processes at the chromatin template significantly sensitize transcriptional and phenotypic outcomes to environmental signaling information including metabolic state, nutritional requirements and history. Epigenetic mechanisms impact gene expression that could predispose individuals to the diabetic phenotype during intrauterine and early postnatal development, as well as throughout adult life. Furthermore, epigenetic changes could account for the accelerated rates of chronic and persistent microvascular and macrovascular complications associated with diabetes. Epidemiological and experimental animal studies identified poor glycemic control as a major contributor to the development of diabetic complications and highlight the requirement for early intervention. Early exposure to hyperglycemia can drive the development of complications that manifest late in the progression of the disease and persist despite improved glycemic control, indicating a memory of the metabolic insult. Understanding the molecular events that underlie these transcriptional changes will significantly contribute to novel therapeutic interventions to prevent, reverse or retard the deleterious effects of the diabetic milieu.