These authors contributed equally to this work.
Polymicrogyria with dysmorphic basal ganglia? Think tubulin!
Version of Record online: 24 APR 2013
© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Volume 85, Issue 2, pages 178–183, February 2014
How to Cite
Amrom, D., Tanyalçin, I., Verhelst, H., Deconinck, N., Brouhard, G.J., Décarie, J.-C., Vanderhasselt, T., Das, S., Hamdan, F.F., Lissens, W., Michaud, J.L. and Jansen, A.C. (2014), Polymicrogyria with dysmorphic basal ganglia? Think tubulin!. Clinical Genetics, 85: 178–183. doi: 10.1111/cge.12141
The authors declare no conflict of interest.
- Issue online: 13 JAN 2014
- Version of Record online: 24 APR 2013
- Accepted manuscript online: 15 MAR 2013 11:42AM EST
- Manuscript Revised: 11 MAR 2013
- Manuscript Accepted: 11 MAR 2013
- Manuscript Received: 23 DEC 2012
- Réseau de Médecine génétique appliquée
- UZ Brussel Onderzoeksraad
|cge12141-sup-0001-FigureS1.tiff||TIFF image||1522K||Figure S1. (a) Conserved residues. The conserved residues of Tubb2b that are in close proximity to GDP are colored green/red. Cα backbone, gray; GDP, magenta with Van der Waals surface, red marks residues in contact with GDP. (b) Partial peptide sequence alignment of human Tubb2b (NP_821080) with FtsZ protein from Methanocaldococcus jannaschii (Q57816), Staphylococcus aureus (P0A031) and Escherichia coli (P0A9A6). Numbers pertain to human Tubb2b sequence. Residues that are in contact with the GDP molecule are colored in red. (c) Box plot of root mean square deviation (RMSD) values for mutated vs wild-type (1TUB, B chain) protein. Three proposed mutated forms of human Tubb2b (two models from SWISS-MODEL Repository, based on 3HKE and 4DRX, one model from I-TASSER, Job ID S109651) have been compared in means of overall RMSD (>300 residues involved), RMSD of the conserved residues depicted in (b) and the geometric mean of RMSD of two random patches upstream and downstream of the conserved sequence (Arg251-Phe260, Met299-Asp304 and Asn14-Val23, Arg62-Asp67) to avoid bias.|
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