cge12152-sup-0001-FigureS1.pdfPDF document30KFigure S1. Pedigrees of EPCAM deletion carrier families. Probands are indicated by an arrow. Cancer localization (CRC, colorectal cancer; GC, gastric cancer; DC, duodenal cancer; ABD, abdominal cancer; LC, lung cancer; CR-p, colorectal polyp) and age at diagnosis are indicated in affected members. Carriers are depicted by dots, obligate carriers by stars and non-carriers by the symbol N.
cge12152-sup-0002-FigureS2.pdfPDF document13KFigure S2. Alignment of the deleted EPCAM alleles with EPCAM intron 7 and 3′ untranslated region (UTR) sequences. The red square indicates the microhomology at the breakpoint region. AluSp and AluSx sequences are highlighted in light and dark grey, respectively. (a) Alignment of the EPCAM c.858+2568_*4596del (g.77526_86198del8673) allele. (b). Alignment of the EPCAM c.858+2488_*7469del (g.77446_89071del11626) allele.
cge12152-sup-0003-FigureS3.pdfPDF document83KFigure S3. Result of the multiplex polymerase chain reaction (PCR)-based diagnostic test of the EPCAM c.858+2568_*4596del (g.77526_86198del8673) in a carrier and a non-carrier individual. Primers b and c amplify a 686-bp fragment specific to the wild-type allele, and primers a and c amplify a 488-bp fragment specific to the deleted allele (location of primers is shown in Fig. 1). Marker lane represents the 100-bp DNA ladder.
cge12152-sup-0004-AppendixS1.pdfPDF document13KAppendix S1. Supplementary methods.

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