The authors declare no conflict of interest.
Preventing ovarian cancer through genetic testing: a population-based study
Article first published online: 4 DEC 2013
© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
How to Cite
Preventing ovarian cancer through genetic testing: a population-based study., , , , , , , , .
- Article first published online: 4 DEC 2013
- Accepted manuscript online: 6 NOV 2013 10:03PM EST
- Manuscript Revised: 4 NOV 2013
- Manuscript Accepted: 4 NOV 2013
- Manuscript Received: 10 SEP 2013
- Canadian Institutes of Health Research
- National Cancer Institute. Grant Numbers: R01 CA 63682, R01 CA 63678
- ovarian cancer;
- personalized medicine
Genetic testing for BRCA1 and BRCA2 gene mutations, in conjunction with preventive salpingo-oophorectomy for mutation carriers, may be used to prevent a proportion of invasive ovarian cancers (‘personalized medicine’). We evaluated the potential utility of this approach at a population level by reviewing the pedigree information and genetic test results from 1342 ovarian cancer patients in Ontario. Of the 1342 patients tested, 176 patients had a BRCA1 or BRCA2 mutation; of these, 48 women would have qualified for testing prior to the development of cancer based on the eligibility criteria in place for the province of Ontario. In summary, 48 of 1342 unselected cases of ovarian cancer (3.6%) might have been prevented if genetic testing criteria were universally applied to all women in Ontario at risk for ovarian cancer.