Get access

Psychological status in female carriers of premutation FMR1 allele showing a complex relationship with the size of CGG expansion

Authors

  • D. Z. Loesch,

    Corresponding author
    1. School of Psychological Science, La Trobe University, Bundoora, Victoria, Australia
    • Corresponding author: Dr Danuta Loesch, La Trobe University, Plenty Rd, Bundoora, Victoria 3083, Australia.

      Tel.: +61 3 9479 1382;

      fax: +61 3 9479 3666;

      e-mail: D.Loesch@latrobe.edu.au

    Search for more papers by this author
  • M. Q. Bui,

    1. Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, Parkville, Victoria, Australia
    Search for more papers by this author
  • E. Hammersley,

    1. School of Psychological Science, La Trobe University, Bundoora, Victoria, Australia
    Search for more papers by this author
  • A. Schneider,

    1. Medical Investigation of Neurodevelopmental Disorders (MIND) Institute, University of California Davis Medical Center, Sacramento, CA, USA
    Search for more papers by this author
  • E. Storey,

    1. Department of Medicine (Neuroscience), Monash University, Melbourne, Victoria, Australia
    Search for more papers by this author
  • P. Stimpson,

    1. Department of Medicine (Neuroscience), Monash University, Melbourne, Victoria, Australia
    Search for more papers by this author
  • T. Burgess,

    1. VCGS Cytogenetics Laboratory, Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia
    Search for more papers by this author
  • D. Francis,

    1. VCGS Cytogenetics Laboratory, Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia
    Search for more papers by this author
  • H. Slater,

    1. VCGS Cytogenetics Laboratory, Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia
    Search for more papers by this author
  • F. Tassone,

    1. Medical Investigation of Neurodevelopmental Disorders (MIND) Institute, University of California Davis Medical Center, Sacramento, CA, USA
    2. Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, Sacramento, CA, USA
    Search for more papers by this author
  • R. J. Hagerman,

    1. Medical Investigation of Neurodevelopmental Disorders (MIND) Institute, University of California Davis Medical Center, Sacramento, CA, USA
    2. Department of Pediatrics, School of Medicine, University of California, Davis, Sacramento, CA, USA
    Search for more papers by this author
  • D. Hessl

    1. Medical Investigation of Neurodevelopmental Disorders (MIND) Institute, University of California Davis Medical Center, Sacramento, CA, USA
    2. Department of Psychiatry and Behavioral Sciences, School of Medicine, University of California, Davis, Sacramento, CA, USA
    Search for more papers by this author

  • Nothing to declare.

Abstract

We utilized a sample of 299 adult females aged between 19 and 86 years, carrying fragile X mental retardation (FMR1) alleles with small CCG expansions ranging from 50 to 141 repeats to analyse the relationships between psychological symptoms as assessed by the Symptom Checklist-90-Revised (SCL-90-R) and the size of the CGG repeat in the FMR1 gene. There were highly significant (negative) correlations between the size of the CGG repeat and a great majority of SCL-90-R subscale scores and all the global indices, suggesting that carriers of premutations in the mid-size CGG repeat range may be at greatest risk for the development of psychiatric disorder.

Get access to the full text of this article

Ancillary