Potentials of Cystatin C and Uric Acid for Predicting Prognosis of Heart Failure
Article first published online: 12 DEC 2012
© 2012 Wiley Periodicals, Inc.
Congestive Heart Failure
Volume 19, Issue 3, pages 123–129, May/June 2013
How to Cite
Kim, H., Yoon, H.-J., Park, H.-S., Cho, Y.-K., Nam, C.-W., Hur, S.-H., Kim, Y.-N. and Kim, K.-B. (2013), Potentials of Cystatin C and Uric Acid for Predicting Prognosis of Heart Failure. Congestive Heart Failure, 19: 123–129. doi: 10.1111/chf.12012
- Issue published online: 3 JUN 2013
- Article first published online: 12 DEC 2012
- Manuscript received: August 4, 2012; revised: September 21, 2012; accepted: September 30, 2012
Few studies have explored the clinical potentials of combined Cystatin C (Cys) and uric acid (UA) in heart failure (HF). The authors evaluated Cys and UA as predictors of clinical outcomes compared with conventional renal biomarkers. This prospective cohort study included 587 HF patients presenting with dyspnea. At admission, Cys, UA, and other renal measures including serum urea nitrogen (BUN), creatinine (Cr), and glomerular filtration rate (GFR) were obtained. The primary endpoint was the composite of cardiac death and rehospitalization for worsening HF. During a 25-month median follow-up period, 68 patients experienced clinical outcomes: 9 cardiac deaths and 59 HFs. They showed higher BUN and Cr values and lower GFR. Within these parameters, Cys and UA had the most favorable area under the curves, and patients with Cys ≥0.8 mg/L and UA ≥6.6 mg/dL showed more frequent events. The net reclassification improvement analysis showed the combination of Cys and UA had a greater incremental effect for cardiac prognosis. On multivariate Cox hazard analysis, Cys and UA were independent predictive markers for clinical outcomes. In HF patients presenting with dyspnea, Cys and UA appear to be more useful predictors of clinical events than other renal measures.