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Figure S1. Outcomes as a function of response to guided therapy, using baseline and final NT-proBNP values. Patients finishing the trial with higher NT-proBNP values had higher event rates, irrespective of baseline value; CV, cardiovascular; NT-proBNP, N-terminal pro B-type natriuretic peptide.

Figure S2. Serial NT-proBNP in two example patients: nonresponder versus responder. A rise in NT-proBNP preceded clinical deterioration in the non-responder; CV, cardiovascular; HM II, HeartMate II; NT-proBNP, N-terminal pro B-type natriuretic peptide.

Figure S3. Cumulative hazard for first cardiovascular event in those with PROTECT risk score ≥3 compared with those with score <3. Patients with risk score ≥3 had higher cumulative hazard.

Table S1. Medications.

Table S2. Adverse events.

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