Can Vitamin D Supplementation Improve the Severity of Congestive Heart Failure?
Article first published online: 20 MAR 2013
© 2013 Wiley Periodicals, Inc.
Congestive Heart Failure
Volume 19, Issue 4, pages E22–E28, July/August 2013
How to Cite
Amin, A., Minaee, S., Chitsazan, M., Naderi, N., Taghavi, S. and Ardeshiri, M. (2013), Can Vitamin D Supplementation Improve the Severity of Congestive Heart Failure?. Congestive Heart Failure, 19: E22–E28. doi: 10.1111/chf.12026
- Issue published online: 1 AUG 2013
- Article first published online: 20 MAR 2013
- Manuscript Accepted: 3 FEB 2013
- Manuscript Revised: 1 FEB 2013
- Manuscript Received: 14 JUN 2012
The aim of the present study was to investigate whether vitamin D supplementation could improve biochemical findings and functional capacity of patients with heart failure (HF). One hundred patients with New York Heart Association (NYHA) class I through III HF were included in this prospective study and their 25-hydroxyvitamin D levels were evaluated. Only 6% of the participants had a sufficient serum concentration of 25(OH) D >30 nmol/L. Patients with insufficient or deficient serum levels of 25(OH) D (<30 ng/mL and <20 ng/mL, respectively) received oral vitamin D3 (cholecalciferol) for a total period of 4 months. Vitamin D supplementation increased mean serum concentration of 25(OH) D from 12.63±7.60 nmol/L to 54.49±18.01 nmol/L (P<.001). After vitamin D supplementation, the serum level of pro-brain natriuretic peptide markedly decreased (P<.001). Cholecalciferol significantly decreased high-sensitivity C-reactive protein level (P<.001). Restoration of serum 25(OH) D level was also associated with substantial improvement in NYHA class (P<.001) and 6-minute walk distance (P<.001).