Uremic Cardiomyopathy: An Underdiagnosed Disease
Article first published online: 25 APR 2013
© 2013 Wiley Periodicals, Inc.
Congestive Heart Failure
Volume 19, Issue 4, pages E40–E45, July/August 2013
How to Cite
Alhaj, E., Alhaj, N., Rahman, I., Niazi, T. O., Berkowitz, R. and Klapholz, M. (2013), Uremic Cardiomyopathy: An Underdiagnosed Disease. Congestive Heart Failure, 19: E40–E45. doi: 10.1111/chf.12030
- Issue published online: 1 AUG 2013
- Article first published online: 25 APR 2013
- Manuscript Accepted: 5 MAR 2013
- Manuscript Revised: 4 MAR 2013
- Manuscript Received: 29 SEP 2012
Uremic cardiomyopathy is responsible for high morbidity and mortality rates among patients with chronic kidney disease (CKD) or end-stage renal disease (ESRD); however, the early implementation of hemodialysis may halt its progression. Nonconventional hemodialysis, such as frequent hemodialysis, appears to have an advantage over conventional hemodialysis. Kidney transplantation has been shown to reverse uremic cardiomyopathy and to confer a significant survival advantage over hemodialysis. Targeting future therapies at the underlying cellular mechanisms of uremic cardiomyopathy may finally start to reduce the burden of uremic cardiomyopathy in the CKD and ESRD population.