Thiamine Supplementation for the Treatment of Heart Failure: A Review of the Literature
Article first published online: 1 AUG 2013
© 2013 Wiley Periodicals, Inc.
Congestive Heart Failure
Volume 19, Issue 4, pages 214–222, July/August 2013
How to Cite
DiNicolantonio, J. J., Niazi, A. K., Lavie, C. J., O'Keefe, J. H. and Ventura, H. O. (2013), Thiamine Supplementation for the Treatment of Heart Failure: A Review of the Literature. Congestive Heart Failure, 19: 214–222. doi: 10.1111/chf.12037
- Issue published online: 1 AUG 2013
- Article first published online: 1 AUG 2013
- Manuscript Accepted: 6 MAY 2013
- Manuscript Received: 16 APR 2013
A systematic review of the literature was performed by searching Pubmed and EMBASE databases using the terms “thiamine,” “vitamin B1,” “heart failure,” “systolic dysfunction,” “ventricular dysfunction,” “cardiomyopathy,” “ventricular failure,” and “systolic failure.” Relevant trials and articles were evaluated pertaining to thiamine deficiency in patients with heart failure (HF) and references were searched for further inclusion of articles. A total of 20 articles were reviewed and summarized in detail. While more research is needed to fully elucidate the clinical thiamine deficiency in HF patients, recent evidence has indicated that supplementing with thiamine in HF patients has the potential to improve left ventricular ejection fraction. Thiamine deficiency appears to be not uncommon in patients with HF, and supplementation with thiamine has been shown to improve cardiac function, urine output, weight loss, and signs and symptoms of HF. Therefore, this simple therapy should be tested in large-scale randomized clinical trial to further determine the effects of thiamine in HF patients.