SEARCH

SEARCH BY CITATION

References

  • Akhtar, A., and Gasser, S.M. (2007) The nuclear envelope and transcriptional control. Nat Rev Genet 8: 507517.
  • Bachmann, A., Predehl, S., May, J., Harder, S., Burchard, G.D., Gilberger, T.W., et al. (2011) Highly co-ordinated var gene expression and switching in clinical Plasmodium falciparum isolates from non-immune malaria patients. Cell Microbiol 9: 13971409.
  • Balu, B., and Adams, J.H. (2006) Functional genomics of Plasmodium falciparum through transposon-mediated mutagenesis. Cell Microbiol 8: 15291536.
  • Bartfai, R., Hoeijmakers, W.A., Salcedo-Amaya, A.M., Smits, A.H., Janssen-Megens, E., Kaan, A., et al. (2010) H2A.Z demarcates intergenic regions of the plasmodium falciparum epigenome that are dynamically marked by H3K9ac and H3K4me3. PLoS Pathog 6: e1001223.
  • Brancucci, N.M., Witmer, K., Schmid, C.D., Flueck, C., and Voss, T.S. (2012) Identification of a cis-acting DNA-protein interaction implicated in singular var gene choice in Plasmodium falciparum. Cell Microbiol 12: 18361848.
  • Brickner, J.H. (2009) Transcriptional memory at the nuclear periphery. Curr Opin Cell Biol 21: 127133.
  • Brolin, K.J., Ribacke, U., Nilsson, S., Ankarklev, J., Moll, K., Wahlgren, M., and Chen, Q. (2009) Simultaneous transcription of duplicated var2csa gene copies in individual Plasmodium falciparum parasites. Genome Biol 10: R117.
  • Calderwood, M.S., Gannoun-Zaki, L., Wellems, T.E., and Deitsch, K.W. (2003) Plasmodium falciparum var genes are regulated by two regions with separate promoters, one upstream of the coding region and a second within the intron. J Biol Chem 278: 3412534132.
  • Chookajorn, T., Dzikowski, R., Frank, M., Li, F., Jiwani, A.Z., Hartl, D.L., and Deitsch, K.W. (2007) Epigenetic memory at malaria virulence genes. Proc Natl Acad Sci USA 104: 899902.
  • Clowney, E.J., Legros, M.A., Mosley, C.P., Clowney, F.G., Markenskoff-Papadimitriou, E.C., Myllys, M., et al. (2012) Nuclear aggregation of olfactory receptor genes governs their monogenic expression. Cell 151: 724737.
  • Cortes, A., Carret, C., Kaneko, O., Yim Lim, B.Y., Ivens, A., and Holder, A.A. (2007) Epigenetic silencing of Plasmodium falciparum genes linked to erythrocyte invasion. PLoS Pathog 3: e107.
  • Cui, L., Fan, Q., Cui, L., and Miao, J. (2008) Histone lysine methyltransferases and demethylases in Plasmodium falciparum. Int J Parasitol 38: 10831097.
  • Deitsch, K.W., Calderwood, M.S., and Wellems, T.E. (2001) Malaria. Cooperative silencing elements in var genes. Nature 412: 875876.
  • Deitsch, K.W., Lukehart, S.A., and Stringer, J.R. (2009) Common strategies for antigenic variation by bacterial, fungal and protozoan pathogens. Nat Rev Microbiol 7: 493503.
  • Duraisingh, M.T., Voss, T.S., Marty, A.J., Duffy, M.F., Good, R.T., Thompson, J.K., et al. (2005) Heterochromatin silencing and locus repositioning linked to regulation of virulence genes in Plasmodium falciparum. Cell 121: 1324.
  • Dzikowski, R., and Deitsch, K.W. (2008) Active transcription is required for maintenance of epigenetic memory in the malaria parasite Plasmodium falciparum. J Mol Biol 382: 288297.
  • Dzikowski, R., Frank, M., and Deitsch, K. (2006) Mutually exclusive expression of virulence genes by malaria parasites is regulated independently of antigen production. PLoS Pathog 2: e22.
  • Dzikowski, R., Li, F., Amulic, B., Eisberg, A., Frank, M., Patel, S., et al. (2007) Mechanisms underlying mutually exclusive expression of virulence genes by malaria parasites. EMBO Rep 8: 959965.
  • Enderes, C., Kombila, D., Dal-Bianco, M., Dzikowski, R., Kremsner, P., and Frank, M. (2011) Var Gene promoter activation in clonal Plasmodium falciparum isolates follows a hierarchy and suggests a conserved switching program that is independent of genetic background. J Infect Dis 204: 16201631.
  • Epp, C., Li, F., Howitt, C.A., Chookajorn, T., and Deitsch, K.W. (2009) Chromatin associated sense and antisense noncoding RNAs are transcribed from the var gene family of virulence genes of the malaria parasite Plasmodium falciparum. RNA 15: 116127.
  • Fastman, Y., Noble, R., Recker, M., and Dzikowski, R. (2012) Erasing the epigenetic memory and beginning to switch – the onset of antigenic switching of var genes in Plasmodium falciparum. PLoS ONE 7: e34168.
  • Flueck, C., Bartfai, R., Volz, J., Niederwieser, I., Salcedo-Amaya, A.M., Alako, B.T., et al. (2009) Plasmodium falciparum heterochromatin protein 1 marks genomic loci linked to phenotypic variation of exported virulence factors. PLoS Pathog 5: e1000569.
  • Frank, M., Dzikowski, R., Costantini, D., Amulic, B., Berdougo, E., and Deitsch, K. (2006) Strict pairing of var promoters and introns is required for var gene silencing in the malaria parasite Plasmodium falciparum. J Biol Chem 281: 99429952.
  • Freitas-Junior, L.H., Hernandez-Rivas, R., Ralph, S.A., Montiel-Condado, D., Ruvalcaba-Salazar, O.K., Rojas-Meza, A.P., et al. (2005) Telomeric heterochromatin propagation and histone acetylation control mutually exclusive expression of antigenic variation genes in malaria parasites. Cell 121: 2536.
  • Horrocks, P., Pinches, R., Christodoulou, Z., Kyes, S.A., and Newbold, C.I. (2004) Variable var transition rates underlie antigenic variation in malaria. Proc Natl Acad Sci USA 101: 1112911134.
  • Howitt, C.A., Wilinski, D., Llinas, M., Templeton, T.J., Dzikowski, R., and Deitsch, K.W. (2009) Clonally variant gene families in Plasmodium falciparum share a common activation factor. Mol Microbiol 73: 11711185.
  • Jiang, L., Lopez-Barragan, M.J., Jiang, H., Mu, J., Gaur, D., Zhao, K., et al. (2010) Epigenetic control of the variable expression of a Plasmodium falciparum receptor protein for erythrocyte invasion. Proc Natl Acad Sci USA 107: 22242229.
  • Kaviratne, M., Khan, S.M., Jarra, W., and Preiser, P.R. (2002) Small variant STEVOR antigen is uniquely located within Maurer's clefts in Plasmodium falciparum-infected red blood cells. Eukaryot Cell 1: 926935.
  • Kyes, S., Christodoulou, Z., Pinches, R., Kriek, N., Horrocks, P., and Newbold, C. (2007) Plasmodium falciparum var gene expression is developmentally controlled at the level of RNA polymerase II-mediated transcription initiation. Mol Microbiol 63: 12371247.
  • Lomvardas, S., Barnea, G., Pisapia, D.J., Mendelsohn, M., Kirkland, J., and Axel, R. (2006) Interchromosomal interactions and olfactory receptor choice. Cell 126: 403413.
  • Lopez-Rubio, J.J., Gontijo, A.M., Nunes, M.C., Issar, N., Hernandez Rivas, R., and Scherf, A. (2007) 5′ flanking region of var genes nucleate histone modification patterns linked to phenotypic inheritance of virulence traits in malaria parasites. Mol Microbiol 66: 12961305.
  • Lopez-Rubio, J.J., Mancio-Silva, L., and Scherf, A. (2009) Genome-wide analysis of heterochromatin associates clonally variant gene regulation with perinuclear repressive centers in malaria parasites. Cell Host Microbe 5: 179190.
  • Magklara, A., Yen, A., Colquitt, B.M., Clowney, E.J., Allen, W., Markenscoff-Papadimitriou, E., et al. (2011) An epigenetic signature for monoallelic olfactory receptor expression. Cell 145: 555570.
  • Malmquist, N.A., Moss, T.A., Mecheri, S., Scherf, A., and Fuchter, M.J. (2012) Small-molecule histone methyltransferase inhibitors display rapid antimalarial activity against all blood stage forms in Plasmodium falciparum. Proc Natl Acad Sci USA 109: 1670816713.
  • Mancio-Silva, L., Zhang, Q., Scheidig-Benatar, C., and Scherf, A. (2010) Clustering of dispersed ribosomal DNA and its role in gene regulation and chromosome-end associations in malaria parasites. Proc Natl Acad Sci USA 107: 1511715122.
  • Merrick, C.J., Huttenhower, C., Buckee, C., Amambua-Ngwa, A., Gomez-Escobar, N., Walther, M., et al. (2012) Epigenetic Dysregulation of virulence gene expression in severe Plasmodium falciparum malaria. J Infect Dis 205: 15931600.
  • Miao, J., Fan, Q., Cui, L., Li, X., Wang, H., Ning, G., et al. (2010) The MYST family histone acetyltransferase regulates gene expression and cell cycle in malaria parasite Plasmodium falciparum. Mol Microbiol 78: 883902.
  • Navarro, M., and Gull, K. (2001) A pol I transcriptional body associated with VSG mono-allelic expression in Trypanosoma brucei. Nature 414: 759763.
  • Noble, R., and Recker, M. (2012) A statistically rigorous method for determining antigenic switching networks. PLoS ONE 7: e39335.
  • Perez-Toledo, K., Rojas-Meza, A.P., Mancio-Silva, L., Hernandez-Cuevas, N.A., Delgadillo, D.M., Vargas, M., et al. (2009) Plasmodium falciparum heterochromatin protein 1 binds to tri-methylated histone 3 lysine 9 and is linked to mutually exclusive expression of var genes. Nucleic Acids Res 37: 25962606.
  • Petter, M., Lee, C.C., Byrne, T.J., Boysen, K.E., Volz, J., Ralph, S.A., et al. (2011) Expression of P. falciparum var genes involves exchange of the histone variant H2A.Z at the promoter. PLoS Pathog 7: e1001292.
  • Ralph, S.A., Scheidig-Benatar, C., and Scherf, A. (2005) Antigenic variation in Plasmodium falciparum is associated with movement of var loci between subnuclear locations. Proc Natl Acad Sci USA 102: 54145419.
  • Recker, M., Buckee, C.O., Serazin, A., Kyes, S., Pinches, R., Christodoulou, Z., et al. (2011) Antigenic variation in Plasmodium falciparum malaria involves a highly structured switching pattern. PLoS Pathog 7: e1001306.
  • Roberts, D.J., Craig, A.G., Berendt, A.R., Pinches, R., Nash, G., Marsh, K., and Newbold, C.I. (1992) Rapid switching to multiple antigenic and adhesive phenotypes in malaria. Nature 357: 689692.
  • Rosenberg, E., Ben-Shmuel, A., Shalev, O., Sinay, R., Cowman, A., and Pollack, Y. (2009) Differential, positional-dependent transcriptional response of antigenic variation (var) genes to biological stress in Plasmodium falciparum. PLoS ONE 4: e6991.
  • Rovira-Graells, N., Gupta, A.P., Planet, E., Crowley, V.M., Mok, S., Ribas de Pouplana, L., et al. (2012) Transcriptional variation in the malaria parasite Plasmodium falciparum. Genome Res 22: 925938.
  • Salcedo-Amaya, A.M., Hoeijmakers, W.A., Bartfai, R., and Stunnenberg, H.G. (2010) Malaria: could its unusual epigenome be the weak spot? Int J Biochem Cell Biol 42: 781784.
  • Scherf, A., Hernandez-Rivas, R., Buffet, P., Bottius, E., Benatar, C., Pouvelle, B., et al. (1998) Antigenic variation in malaria: in situ switching, relaxed and mutually exclusive transcription of var genes during intra-erythrocytic development in Plasmodium falciparum. EMBO J 17: 54185426.
  • Scherf, A., Lopez-Rubio, J.J., and Riviere, L. (2008) Antigenic variation in Plasmodium falciparum. Annu Rev Microbiol 62: 445470.
  • Schieck, E., Pfahler, J.M., Sanchez, C.P., and Lanzer, M. (2007) Nuclear run-on analysis of var gene expression in Plasmodium falciparum. Mol Biochem Parasitol 153: 207212.
  • Serizawa, S., Miyamichi, K., Nakatani, H., Suzuki, M., Saito, M., Yoshihara, Y., and Sakano, H. (2003) Negative feedback regulation ensures the one receptor-one olfactory neuron rule in mouse. Science 302: 20882094.
  • Sierra-Miranda, M., Delgadillo, D.M., Mancio-Silva, L., Vargas, M., Villegas-Sepulveda, N., Martinez-Calvillo, S., et al. (2012) Two long non-coding RNAs generated from subtelomeric regions accumulate in a novel perinuclear compartment in Plasmodium falciparum. Mol Biochem Parasitol 185: 3647.
  • Simonis, M., Klous, P., Splinter, E., Moshkin, Y., Willemsen, R., de Wit, E., et al. (2006) Nuclear organization of active and inactive chromatin domains uncovered by chromosome conformation capture-on-chip (4C). Nat Genet 38: 13481354.
  • Swamy, L., Amulic, B., and Deitsch, K.W. (2011) Plasmodium falciparum var gene silencing is determined by cis DNA elements that form stable and heritable interactions. Eukaryot Cell 10: 530539.
  • Tonkin, C.J., Carret, C.K., Duraisingh, M.T., Voss, T.S., Ralph, S.A., Hommel, M., et al. (2009) Sir2 paralogues cooperate to regulate virulence genes and antigenic variation in Plasmodium falciparum. PLoS Biol 7: e84.
  • Volz, J.C., Bartfai, R., Petter, M., Langer, C., Josling, G.A., Tsuboi, T., et al. (2012) PfSET10, a Plasmodium falciparum methyltransferase, maintains the active var gene in a poised state during parasite division. Cell Host Microbe 11: 718.
  • Voss, T.S., Healer, J., Marty, A.J., Duffy, M.F., Thompson, J.K., Beeson, J.G., et al. (2006) A var gene promoter controls allelic exclusion of virulence genes in Plasmodium falciparum malaria. Nature 439: 10041008.
  • Zhang, Q., Huang, Y., Zhang, Y., Fang, X., Claes, A., Duchateau, M., et al. (2011a) A critical role of perinuclear filamentous actin in spatial repositioning and mutually exclusive expression of virulence genes in malaria parasites. Cell Host Microbe 10: 451463.
  • Zhang, Q., Zhang, Y., Huang, Y., Xue, X., Yan, H., Sun, X., et al. (2011b) From in vivo to in vitro: dynamic analysis of Plasmodium falciparum var gene expression patterns of patient isolates during adaptation to culture. PLoS ONE 6: e20591.