Dysfunctions at human intestinal barrier by water-borne protozoan parasites: lessons from cultured human fully differentiated colon cancer cell lines

Authors

  • Vanessa Liévin-Le Moal

    Corresponding author
    1. University Paris-Sud, Faculty of Pharmacy, Châtenay-Malabry, France
    • CNRS, UMR 8076 «BioCIS». Team «Antiparasitic chemotherapy». Faculty of Pharmacy, Châtenay-Malabry, France
    Search for more papers by this author

For correspondence. E-mail vanessa.lievin-le-moal@u-psud.fr; Tel. (+33) 1 46 83 52 90; Fax (+33) 1 46 83 55 24.

Summary

Some water-borne protozoan parasites induce diseases through their membrane-associated functional structures and virulence factors that hijack the host cellular molecules and signalling pathways leading to structural and functional lesions in the intestinal barrier. In this Microreview we analyse the insights on the mechanisms of pathogenesis of Entamoeba intestinalis, Giardia and Cryptosporidium observed in the human colon carcinoma fully differentiated colon cancer cell lines, cell subpopulations and clones expressing the structural and functional characteristics of highly specialized fully differentiated epithelial cells lining the intestinal epithelium and mimicking structurally and functionally an intestinal barrier.

Ancillary