The inner membrane complex through development of Toxoplasma gondii and Plasmodium
Article first published online: 21 MAR 2014
© 2014 The Authors. Cellular Microbiology published by John Wiley & Sons Ltd.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Special Issue: Malaria
Volume 16, Issue 5, pages 632–641, May 2014
How to Cite
Harding, C. R. and Meissner, M. (2014), The inner membrane complex through development of Toxoplasma gondii and Plasmodium. Cellular Microbiology, 16: 632–641. doi: 10.1111/cmi.12285
- Issue published online: 15 APR 2014
- Article first published online: 21 MAR 2014
- Accepted manuscript online: 26 FEB 2014 02:21AM EST
- Manuscript Revised: 20 FEB 2014
- Manuscript Accepted: 20 FEB 2014
- Manuscript Received: 31 JAN 2014
- Wellcome Trust. Grant Number: 087582/Z/08/Z
- ERC. Grant Number: ERC-2012-StG 309255
Plasmodium spp. and Toxoplasma gondii are important human and veterinary pathogens. These parasites possess an unusual double membrane structure located directly below the plasma membrane named the inner membrane complex (IMC). First identified in early electron micrograph studies, huge advances in genetic manipulation of the Apicomplexa have allowed the visualization of a dynamic, highly structured cellular compartment with important roles in maintaining the structure and motility of these parasites. This review summarizes recent advances in the field and highlights the changes the IMC undergoes during the complex life cycles of the Apicomplexa.