Intracellular killing of bacteria: is Dictyostelium a model macrophage or an alien?
Version of Record online: 4 APR 2014
© 2014 The Authors. Cellular Microbiology published by John Wiley & Sons Ltd.
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
Volume 16, Issue 6, pages 816–823, June 2014
How to Cite
Cosson, P. and Lima, W. C. (2014), Intracellular killing of bacteria: is Dictyostelium a model macrophage or an alien?. Cellular Microbiology, 16: 816–823. doi: 10.1111/cmi.12291
- Issue online: 16 MAY 2014
- Version of Record online: 4 APR 2014
- Accepted manuscript online: 16 MAR 2014 09:34PM EST
- Manuscript Accepted: 10 MAR 2014
- Manuscript Revised: 6 MAR 2014
- Manuscript Received: 27 JAN 2014
Predation of bacteria by phagocytic cells was first developed during evolution by environmental amoebae. Many of the core mechanisms used by amoebae to sense, ingest and kill bacteria have also been conserved in specialized phagocytic cells in mammalian organisms. Here we focus on recent results revealing how Dictyostelium discoideum senses and kills non-pathogenic bacteria. In this model, genetic analysis of intracellular killing of bacteria has revealed a surprisingly complex array of specialized mechanisms. These results raise new questions on these processes, and challenge current models based largely on studies in mammalian phagocytes. In addition, recent studies suggest one additional level on complexity by revealing how Dictyostelium recognizes specifically various bacterial species and strains, and adapts its metabolism to process them. It remains to be seen to what extent mechanisms uncovered in Dictyostelium are also used in mammalian phagocytic cells.