Natalia de Miguel, Angelica Riestra and Patricia J. Johnson
In this issue, de Miguel et al. describe a tetraspanin membrane protein (TvTSP6) of the extracellular parasite Trichomonas vaginalis that is reversibly redistributed upon contact with host cells. TvTSP6 is predominantly localized on the parasite's flagellar membrane in the absence of host cells; it is initially redistributed to intracellular vesicles and the plasma membrane upon adherence to host cells and later returns to the flagella. Possible roles for TvTSP6 in host cell sensing via outside-in signaling and migration in the host are discussed.