Cell entry of Lassa virus induces tyrosine phosphorylation of dystroglycan (pages 689–700)
Marie-Laurence Moraz, Christelle Pythoud, Rolf Turk, Sylvia Rothenberger, Antonella Pasquato, Kevin P. Campbell and Stefan Kunz
Version of Record online: 20 DEC 2012 | DOI: 10.1111/cmi.12078
Virus binding to cellular receptors frequently induces signaling that serves as a “knock on the door” to prime the host cell for subsequent steps of viral entry. Here, we found that binding of the highly pathogenic Lassa virus to its cellular receptor dystroglycan induces signaling, resulting in tyrosine phosphorylation of the cytoplasmic domain of the receptor. These signaling events are accompanied by the dissociation of dystroglycan from the cytoskeletal adaptor protein utrophin, likely facilitating internalization of the virus-receptor complex.