Electron tomography of Plasmodium falciparum merozoites reveals core cellular events that underpin erythrocyte invasion (pages 1457–1472)
Eric Hanssen, Chaitali Dekiwadia, David T. Riglar, Melanie Rug, Leandro Lemgruber, Alan F. Cowman, Marek Cyrklaff, Mikhail Kudryashev, Friedrich Frischknecht, Jake Baum and Stuart A. Ralph
Version of Record online: 22 MAR 2013 | DOI: 10.1111/cmi.12132
Invasion of the human erythrocyte by Plasmodium parasites is critical for establishment of malaria disease. Over several decades researchers have developed a detailed molecular map of events underpinning invasion, however, cellular understanding of entry by P. falciparum – the parasite responsible for most mortality from malaria – has remained limited. In this issue, Hanssen and Dekiwadia et al. address this shortcoming, presenting the first 3D study of invasion using state-of-the-art electron microscopy to reveal high-definition insights into this key step in parasite biology.