Cellular Microbiology

Cover image for Vol. 16 Issue 8

August 2014

Volume 16, Issue 8

Pages i–ii, 1133–1283

  1. Issue Information

    1. Top of page
    2. Issue Information
    3. Editor’s Choice
    4. Thematic Reviews – NADPH Oxidases in Innate Immunity
    5. Original articles
  2. Editor’s Choice

    1. Top of page
    2. Issue Information
    3. Editor’s Choice
    4. Thematic Reviews – NADPH Oxidases in Innate Immunity
    5. Original articles
    1. Anaplasma phagocytophilum surface protein AipA mediates invasion of mammalian host cells (pages 1133–1145)

      David Seidman, Nore Ojogun, Naomi J. Walker, Juliana Mastronunzio, Amandeep Kahlon, Kathryn S. Hebert, Sophia Karandashova, Daniel P. Miller, Brittney K. Tegels, Richard T. Marconi, Erol Fikrig, Dori L. Borjesson and Jason A. Carlyon

      Article first published online: 3 APR 2014 | DOI: 10.1111/cmi.12286

      Thumbnail image of graphical abstract

      Anaplasma phagocytophilum is an obligate intracellular bacterium that utilizes multiple surface proteins called invasins that act cooperatively to mediate entry into host cells. Blocking infection therefore requires simultaneous targeting of the relevant invasins. Herein, we identify a novel A. phagocytophilum invasin, AipA, delineate its invasion domain, and demonstrate that antibodies targeting AipA together with two additional invasins – OmpA and Asp14 – block infection of host cells. Our work evidences the potential of multi-target approaches for preventing infections by intracellular bacteria.

  3. Thematic Reviews – NADPH Oxidases in Innate Immunity

    1. Top of page
    2. Issue Information
    3. Editor’s Choice
    4. Thematic Reviews – NADPH Oxidases in Innate Immunity
    5. Original articles
    1. Microreviews

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  4. Original articles

    1. Top of page
    2. Issue Information
    3. Editor’s Choice
    4. Thematic Reviews – NADPH Oxidases in Innate Immunity
    5. Original articles
    1. An L2 SUMO interacting motif is important for PML localization and infection of human papillomavirus type 16 (pages 1179–1200)

      Timo Bund, Gilles A. Spoden, Kaloian Koynov, Nadja Hellmann, Fatima Boukhallouk, Philipp Arnold, Dariush Hinderberger and Luise Florin

      Article first published online: 12 MAR 2014 | DOI: 10.1111/cmi.12271

    2. The chlamydial organism Simkania negevensis forms ER vacuole contact sites and inhibits ER-stress (pages 1224–1243)

      Adrian Mehlitz, Karthika Karunakaran, Jo-Ana Herweg, Georg Krohne, Sebastian van de Linde, Elke Rieck, Markus Sauer and Thomas Rudel

      Article first published online: 21 MAR 2014 | DOI: 10.1111/cmi.12278

    3. Central role of PAFR signalling in ExoU-induced NF-κB activation (pages 1244–1254)

      Carolina Diettrich Mallet de Lima, Jessica da Conceição Costa, Sabrina Alves de Oliveira Lima Santos, Simone Carvalho, Laís de Carvalho, Rodolpho Mattos Albano, Mauro Martins Teixeira, Maria Cristina Maciel Plotkowski and Alessandra Mattos Saliba

      Article first published online: 21 MAR 2014 | DOI: 10.1111/cmi.12280

    4. You have full text access to this OnlineOpen article

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