The first two authors contributed equally to this work.
Clinical Features and Sera Anti-Aquaporin 4 Antibody Positivity in Patients with Demyelinating Disorders of the Central Nervous System from Tianjin, China
Article first published online: 27 JUL 2013
© 2013 John Wiley & Sons Ltd
CNS Neuroscience & Therapeutics
Volume 20, Issue 1, pages 32–39, January 2014
How to Cite
Yang, C.-S., Zhang, D.-Q., Wang, J.-H., Jin, W.-N., Li, M.-S., Liu, J., Zhang, C.-J., Li, T., Shi, F.-D. and Yang, L. (2014), Clinical Features and Sera Anti-Aquaporin 4 Antibody Positivity in Patients with Demyelinating Disorders of the Central Nervous System from Tianjin, China. CNS Neuroscience & Therapeutics, 20: 32–39. doi: 10.1111/cns.12156
- Issue published online: 16 DEC 2013
- Article first published online: 27 JUL 2013
- Manuscript Accepted: 4 JUL 2013
- Manuscript Revised: 1 JUL 2013
- Manuscript Received: 4 MAY 2013
- Tianjin Educational Committee. Grant Number: 20100130
- National Natural Science Foundation of China. Grant Numbers: 81171183, 81230028
- China National Basic Research Program. Grant Number: 2013CB966900
- Anti-aquaporin 4 antibody;
- Clinical features;
- Multiple sclerosis;
- Neuromyelitis optica
To investigate the clinical characteristics and sera anti-aquaporin 4 (AQP4) antibody positivity in patients with inflammatory demyelinating disorders (IDDs) of the central nervous system (CNS) in Tianjin, China.
We retrospectively evaluated 234 patients with IDDs including neuromyelitis optica (NMO), recurrent optic neuritis (rON), longitudinally extensive transverse myelitis (LETM), clinically isolated syndrome (CIS), and multiple sclerosis (MS) groups. Sera from 217 patients were determined for AQP4-Ab. The clinical characteristics and sera anti-AQP4 positivity were compared.
The IDDS comprised 63 MS, 51 NMO, 56 LETM, 10 rON, and 54 CIS. Compared with MS, NMO had a higher frequency of occurrence in women, intractable hiccup and nausea (IHN), medullospinal lesion, longitudinally extensive spinal cord lesions (LESCL) and bilateral ON, disease onset at a later age, and worsening residual disability. AQP4-Ab-positive rates were 84.1% and 69% in NMO and NMO spectrum disorders (NMOSD), respectively, whereas it was undetectable in all of the MS sera samples.
We comprehensively contrast the distinct clinical features of MS, NMO, and NMOSD in our center. A sensitive AQP4-Ab assay is necessary for the early diagnosis of NMOSD in our patients. Neither medullospinal lesion nor IHN is unique in NMO.