Clinical Features and Sera Anti-Aquaporin 4 Antibody Positivity in Patients with Demyelinating Disorders of the Central Nervous System from Tianjin, China

Authors

  • Chun-Sheng Yang,

    1. Department of Neurology and Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China
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  • Da-Qi Zhang,

    1. Department of Neurology and Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China
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  • Jing-Hua Wang,

    1. Department of Neurology and Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China
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  • Wei-Na Jin,

    1. Department of Neurology and Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China
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  • Min-Shu Li,

    1. Department of Neurology and Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China
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  • Jie Liu,

    1. Department of Neurology and Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China
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  • Cun-Jin Zhang,

    1. Department of Neurology and Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China
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  • Ting Li,

    1. Department of Neurology and Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China
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  • Fu-Dong Shi,

    1. Department of Neurology and Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China
    2. Department of Neurology and Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA
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  • Li Yang

    Corresponding author
    1. Department of Neurology and Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China
    • Correspondence

      L. Yang, M.D., Ph.D., Department of Neurology and Tianjin Neurological Institute, Tianjin Medical University, Tianjin 300052, China.

      Tel.: +86-22-608-14602;

      Fax: +86-22-608-17471;

      E-mail: yungli2001@yahoo.com

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  • The first two authors contributed equally to this work.

Summary

Aims

To investigate the clinical characteristics and sera anti-aquaporin 4 (AQP4) antibody positivity in patients with inflammatory demyelinating disorders (IDDs) of the central nervous system (CNS) in Tianjin, China.

Methods

We retrospectively evaluated 234 patients with IDDs including neuromyelitis optica (NMO), recurrent optic neuritis (rON), longitudinally extensive transverse myelitis (LETM), clinically isolated syndrome (CIS), and multiple sclerosis (MS) groups. Sera from 217 patients were determined for AQP4-Ab. The clinical characteristics and sera anti-AQP4 positivity were compared.

Results

The IDDS comprised 63 MS, 51 NMO, 56 LETM, 10 rON, and 54 CIS. Compared with MS, NMO had a higher frequency of occurrence in women, intractable hiccup and nausea (IHN), medullospinal lesion, longitudinally extensive spinal cord lesions (LESCL) and bilateral ON, disease onset at a later age, and worsening residual disability. AQP4-Ab-positive rates were 84.1% and 69% in NMO and NMO spectrum disorders (NMOSD), respectively, whereas it was undetectable in all of the MS sera samples.

Conclusions

We comprehensively contrast the distinct clinical features of MS, NMO, and NMOSD in our center. A sensitive AQP4-Ab assay is necessary for the early diagnosis of NMOSD in our patients. Neither medullospinal lesion nor IHN is unique in NMO.

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