Neuroprotective Potential of Silymarin against CNS Disorders: Insight into the Pathways and Molecular Mechanisms of Action

Authors

  • Anupom Borah,

    Corresponding author
    1. Cellular and Molecular Neurobiology Laboratory, Department of Life Science and Bioinformatics, Assam University, Silchar, India
    • Correspondence

      Anupom Borah, Ph.D., Cellular and Molecular Neurobiology Laboratory, Department of Life Science and Bioinformatics, Assam University, Silchar 788011, Assam, India.

      Tel.: +91-9435176880;

      Fax: +91-3842-20802;

      E-mail: anupomborah@gmail.com; anupom.borah@aus.ac.in

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  • Rajib Paul,

    1. Cellular and Molecular Neurobiology Laboratory, Department of Life Science and Bioinformatics, Assam University, Silchar, India
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  • Sabanum Choudhury,

    1. Cellular and Molecular Neurobiology Laboratory, Department of Life Science and Bioinformatics, Assam University, Silchar, India
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  • Amarendranath Choudhury,

    1. Cellular and Molecular Neurobiology Laboratory, Department of Life Science and Bioinformatics, Assam University, Silchar, India
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  • Bornalee Bhuyan,

    1. Ethnobotany and Medicinal Plant Laboratory, Department of Life Science and Bioinformatics, Assam University, Silchar, India
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  • Anupam Das Talukdar,

    1. Ethnobotany and Medicinal Plant Laboratory, Department of Life Science and Bioinformatics, Assam University, Silchar, India
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  • Manabendra Dutta Choudhury,

    1. Ethnobotany and Medicinal Plant Laboratory, Department of Life Science and Bioinformatics, Assam University, Silchar, India
    2. Assam University Biotech Hub (DBT), Assam University, Silchar, India
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  • Kochupurackal P Mohanakumar

    1. Laboratory of Clinical & Experimental Neuroscience, Division of Cell Biology & Physiology, CSIR-Indian Institute of Chemical Biology, Jadavpur, India
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Summary

Silymarin, a C25 containing flavonoid from the plant Silybum marianum, has been the gold standard drug to treat liver disorders associated with alcohol consumption, acute and chronic viral hepatitis, and toxin-induced hepatic failures since its discovery in 1960. Apart from the hepatoprotective nature, which is mainly due to its antioxidant and tissue regenerative properties, Silymarin has recently been reported to be a putative neuroprotective agent against many neurologic diseases including Alzheimer's and Parkinson's diseases, and cerebral ischemia. Although the underlying neuroprotective mechanism of Silymarin is believed to be due to its capacity to inhibit oxidative stress in the brain, it also confers additional advantages by influencing pathways such as β-amyloid aggregation, inflammatory mechanisms, cellular apoptotic machinery, and estrogenic receptor mediation. In this review, we have elucidated the possible neuroprotective effects of Silymarin and the underlying molecular events, and suggested future courses of action for its acceptance as a CNS drug for the treatment of neurodegenerative diseases.

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