Allogeneic Head and Body Reconstruction: Mouse Model

Authors

  • Xiao-Ping Ren,

    Corresponding author
    1. Hand and Microsurgical Center, the Second Affiliated Hospital of Harbin Medical University, Harbin, China
    2. State-Province Key Laboratories of Biomedicine-Pharmaceutics, Harbin Medical University, Harbin, China
    3. Department of Molecular Pharmacology & Therapeutics, Stritch School of Medicine, Loyola University Chicago, Chicago, IL, USA
    • Correspondence

      Prof. Xiao-Ping Ren, MD, Hand and Microsurgical Center, The Second Affiliated Hospital, Harbin Medical University, 194 Xuefu Road, Nangang District, Harbin 150081, China.

      Tel.: +86-13644606583;

      Fax: +86-451-8669-9363-1363;

      E-mail: xren2@luc.edu

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  • Yang Song,

    1. Hand and Microsurgical Center, the Second Affiliated Hospital of Harbin Medical University, Harbin, China
    2. State-Province Key Laboratories of Biomedicine-Pharmaceutics, Harbin Medical University, Harbin, China
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  • Yi-Jie Ye,

    1. Hand and Microsurgical Center, the Second Affiliated Hospital of Harbin Medical University, Harbin, China
    2. State-Province Key Laboratories of Biomedicine-Pharmaceutics, Harbin Medical University, Harbin, China
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  • Peng-Wei Li,

    1. Hand and Microsurgical Center, the Second Affiliated Hospital of Harbin Medical University, Harbin, China
    2. State-Province Key Laboratories of Biomedicine-Pharmaceutics, Harbin Medical University, Harbin, China
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  • Ke-Cheng Han,

    1. Hand and Microsurgical Center, the Second Affiliated Hospital of Harbin Medical University, Harbin, China
    2. State-Province Key Laboratories of Biomedicine-Pharmaceutics, Harbin Medical University, Harbin, China
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  • Zi-Long Shen,

    1. Hand and Microsurgical Center, the Second Affiliated Hospital of Harbin Medical University, Harbin, China
    2. State-Province Key Laboratories of Biomedicine-Pharmaceutics, Harbin Medical University, Harbin, China
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  • Ji-Gang Shan,

    1. Hand and Microsurgical Center, the Second Affiliated Hospital of Harbin Medical University, Harbin, China
    2. State-Province Key Laboratories of Biomedicine-Pharmaceutics, Harbin Medical University, Harbin, China
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  • Kristin Luther,

    1. Department of Molecular Pharmacology & Therapeutics, Stritch School of Medicine, Loyola University Chicago, Chicago, IL, USA
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  • Bao-Feng Yang

    1. State-Province Key Laboratories of Biomedicine-Pharmaceutics, Harbin Medical University, Harbin, China
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Summary

Aims

There is still no effective way to save a surviving healthy mind when there is critical organ failure in the body. The next frontier in CTA is allo-head and body reconstruction (AHBR), and just as animal models were key in the development of CTA, they will be crucial in establishing the procedures of AHBR for clinical translation.

Methods and results

Our approach, pioneered in mice, involves retaining the donor brain stem and transplanting the recipient head. Our preliminary data in mice support that this allows for retention of breathing and circulatory function. Critical aspects of the current protocol include avoiding cerebral ischemia through cross-circulation (donor to recipient) and retaining the donor brain stem. Successful clinical translation of AHBR will become a milestone of medical history and potentially could save millions of people.

Conclusions

This experimental study has confirmed a method to avoid cerebral ischemia during the surgery and solved an important part of the problem of how to accomplish long-term survival after transplantation and preservation of the donor brain stem.

Ancillary