Risk of coronary artery disease is not linked to head and neck cancers: a population-based retrospective cohort study

Authors

  • L.-M. Sun,

    1. Department of Radiation Oncology, Zuoying Armed Forces General Hospital, Kaohsiung
    Search for more papers by this author
  • J.-A. Liang,

    1. Department of Radiation Oncology
    2. Graduate Institute of Clinical Medical Science and School of Medicine, College of Medicine
    Search for more papers by this author
  • S.-N. Chang,

    1. The Ph.D. Program for Cancer Biology and Drug Discovery
    2. Institute of Environmental Health, College of Public Health, China Medical University, Taichung
    3. Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    Search for more papers by this author
  • F.-C. Sung,

    1. Institute of Environmental Health, College of Public Health, China Medical University, Taichung
    2. Management Office for Health Data
    Search for more papers by this author
  • C.-H. Muo,

    1. Institute of Environmental Health, College of Public Health, China Medical University, Taichung
    2. Management Office for Health Data
    Search for more papers by this author
  • C.-H. Kao

    1. Graduate Institute of Clinical Medical Science and School of Medicine, College of Medicine
    2. Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan
    Search for more papers by this author

  • Li-Min Sun and Chih-Hsin Muo contributed equally to this work.

C.-H. Kao, Department of Nuclear Medicine and PET Center, China Medical University Hospital, No. 2, Yuh-Der Road, Taichung 404, Taiwan.
Tel.: +886 4 22052121 x 7412; Fax: +886 4 22336174; e-mail: d10040@mail.cmuh.org.tw

Abstract

Clin. Otolaryngol. 2012, 37, 369–375

Objectives:  To explore the possible association between the risk of coronary artery disease and head or neck cancer based on some possible shared risk factors and/or treatment-related complications.

Design and setting:  A population-based retrospective cohort study.

Participants:  All new 729 patients with head and neck cancer diagnosed between 2000 and 2003 were followed up till 2009, and the risk of subsequent coronary artery disease was calculated. For each patient, the risk was calculated in 4 age-and sex-matched population controls. Matching was not possible for factors including socio-economic group and smoking.

Main outcome measures:  Cox’s proportional hazard regression analysis was conducted to estimate the relationship between head or neck cancer and risk of coronary artery disease.

Results:  For patients with head or neck cancer, the overall risk for developing coronary artery disease was almost the same as that of the control group [adjusted hazard ratio (but without control for some lifestyle factors): 0.95; 95% confidence interval: 0.65–1.35]. Overall, we found no increased risk of coronary artery disease for patients with head or neck cancer when the data were categorised either by treatment methods or by cancer subsites.

Conclusions:  This population-based study indicated that patients with head or neck cancer were at no higher risk of developing coronary artery disease than was the general population over a 6- to 9-year period; however, we cannot exclude the risk over a longer period of time.

Ancillary