Shared first authorship.
Efficacy and safety of long-term low-calorie diet in severely obese patients non-eligible for surgery
Article first published online: 14 MAY 2013
© 2013 The Authors. Clinical Obesity © 2013 International Association for the Study of Obesity
Volume 3, Issue 3-4, pages 90–94, June-August 2013
How to Cite
Alabdali, F., Rueda-Clausen, C. F., Robbins, S. and Sharma, A. M. (2013), Efficacy and safety of long-term low-calorie diet in severely obese patients non-eligible for surgery. Clinical Obesity, 3: 90–94. doi: 10.1111/cob.12017
- Issue published online: 15 JUL 2013
- Article first published online: 14 MAY 2013
- Manuscript Accepted: 13 APR 2013
- Manuscript Revised: 9 APR 2013
- Manuscript Received: 5 MAR 2013
- CIHR and AI-HS
- low-calorie diet;
- severely obese
The aim of this study was to describe the long-term efficacy and safety of low-calorie diets (LCDs; providing 900 kcal day−1) in obese patients who have failed to achieve adequate weight loss with standard medical management and are non-eligible for surgical therapeutic options. Charts from a regional hospital-based outpatient bariatric programme were reviewed. Eight patients (75% male, age 60.1 ± 7.8 years) with severe obesity (body mass index 57.1 ± 8.8 kg m−2) and undergoing long-term LCD (33 ± 10 months) were identified. Variables of interest included anthropometric, cardiovascular risk and nutritional parameters, thyroid, renal and liver function, changes in medications, side effects and adverse events. Average weight loss was 44 ± 15 kg (27 ± 13% of initial weight) at 24 months. Long-term management with LCD resulted in substantial and sustained improvements in glucose homeostasis, blood pressure and lipid profile. LCD was well tolerated with minor self-limited side effects. Over the follow-up period, two subjects underwent coronary revascularization and one patient underwent knee replacement surgery – all recovered without complications. These findings suggest that in selected obese patients (non-eligible for surgery), long-term management with LCD may provide an alternative option for substantial and sustainable weight loss with significant improvements in metabolic and cardiovascular health.