Sensitization patterns in Compositae-allergic patients with current or past atopic dermatitis

Authors

  • Evy Paulsen,

    Corresponding author
    1. Department of Dermatology and Allergy Centre, Odense University Hospital, University of Southern Denmark, Odense DK-5000, Denmark
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  • Klaus E. Andersen

    1. Department of Dermatology and Allergy Centre, Odense University Hospital, University of Southern Denmark, Odense DK-5000, Denmark
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  • Conflicts of interest: The authors have declared no conflicts.

Evy Paulsen, Department of Dermatology and Allergy Centre, Odense University Hospital, Sdr. Boulevard 29, DK-5000 Odense C, Denmark. Tel: +45 6541 2705; Fax: +45 6612 3819. E-mail: evy.paulsen@ouh.regionsyddanmark.dk

Abstract

Background. An association between Compositae sensitization and atopic dermatitis has been suggested on the basis of case reports and clinical studies.

Objectives. To describe the characteristics of sensitization in Compositae-allergic patients with current and/or past atopic dermatitis.

Patients/materials/methods. Consecutive Compositae-sensitive patients were selected for analysis if they had a history of (i) present and/or past atopic dermatitis or (ii) childhood flexural eczema or (iii) childhood eczema of any kind and a positive prick test result.

Results. Fifty-one persons (35 females and 16 males) were included. The mean age was lower and the percentage of males was slightly higher than in non-atopics. Testing with sesquiterpene lactone mix, parthenolide and Compositae mix 6% or 5% detected 96% of the patients. Occupational sensitization occurred in 22%. The sensitizing pattern did not differ much from that of non-atopics, except that dandelion was an important allergen in children. Cobalt allergy was the most frequent other contact allergy, occurring in 37%.

Conclusions. Persons with current or past atopic dermatitis may become sensitized to Compositae at any age, both occupationally and non-occupationally. They should be screened for Compositae allergy on equal terms with non-atopics, except that dandelion extract should always be tested in children. Co-sensitization to cobalt was frequent, but probably not related to the plant allergy.

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