Conflicts of interest: Margarida Gonçalo: Participation in the ‘EDEN study on the prevalence of contact allergy in Europe’, partially financed by RIFM.
Contact allergy to common ingredients in hair dyes
Article first published online: 19 JUN 2013
© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Volume 69, Issue 1, pages 32–39, July 2013
How to Cite
Søsted, H., Rustemeyer, T., Gonçalo, M., Bruze, M., Goossens, A., Giménez-Arnau, A. M., Le Coz, C. J., White, I. R., Diepgen, T. L., Andersen, K. E., Agner, T., Maibach, H., Menné, T. and Johansen, J. D. (2013), Contact allergy to common ingredients in hair dyes. Contact Dermatitis, 69: 32–39. doi: 10.1111/cod.12077
- Issue published online: 19 JUN 2013
- Article first published online: 19 JUN 2013
- Manuscript Accepted: 9 FEB 2013
- Manuscript Revised: 29 JAN 2013
- Manuscript Received: 17 JAN 2013
- hair dye allergy;
p-Phenylenediamine (PPD) is the primary patch test screening agent for hair dye contact allergy, and approximately 100 different hair dye chemicals are allowed.
To examine whether PPD is an optimal screening agent for diagnosing hair dye allergy or whether other clinically important sensitizers exist.
Two thousand nine hundred and thirty-nine consecutive patients in 12 dermatology clinics were patch tested with five hair dyes available from patch test suppliers. Furthermore, 22 frequently used hair dye ingredients not available from patch test suppliers were tested in subgroups of ∼ 500 patients each.
A positive reaction to PPD was found in 4.5% of patients, and 2.8% reacted to toluene-2,5-diamine (PTD), 1.8% to p-aminophenol, 1% to m-aminophenol, and 0.1% to resorcinol; all together, 5.3% (n = 156). Dying hair was the most frequently reported cause of the allergy (55.4%); so-called ‘temporary henna’ tattoos were the cause in 8.5% of the cases. p-Methylaminophenol gave a reaction in 20 patients (2.2%), 3 of them with clinical relevance, and no co-reaction with the above five well-known hair dyes.
Hair dyes are the prime cause of PPD allergy. PPD identifies the majority of positive reactions to PTD, p-aminophenol and m-aminophenol, but not all, which justifies additional testing with hair dye ingredients from the used product.