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Prognostic significance of apical lymph node metastasis in patients with node-positive rectal cancer

Authors

  • J. Peng,

    1. Department of Colorectal Surgery, Shanghai Cancer Center, Fudan University, Shanghai, China
    2. Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
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    • Both authors contributed equally to this paper.
  • H. Wu,

    1. Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
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    • Both authors contributed equally to this paper.
  • X. Li,

    1. Department of Colorectal Surgery, Shanghai Cancer Center, Fudan University, Shanghai, China
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  • W. Sheng,

    1. Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
    2. Department of Pathology, Fudan University, Cancer Hospital, Shanghai, China
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  • D. Huang,

    1. Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
    2. Department of Pathology, Fudan University, Cancer Hospital, Shanghai, China
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  • Z. Guan,

    1. Department of Colorectal Surgery, Shanghai Cancer Center, Fudan University, Shanghai, China
    2. Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
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  • M. Wang,

    1. Department of Colorectal Surgery, Shanghai Cancer Center, Fudan University, Shanghai, China
    2. Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
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  • S. Cai

    Corresponding author
    1. Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
    • Department of Colorectal Surgery, Shanghai Cancer Center, Fudan University, Shanghai, China
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Correspondence to: Prof. Sanjun Cai, Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, 270 Dong An Road, Shanghai 200032, China

E-mail: caisanjun@gmail.com

Abstract

Aim

The aim of this study was to assess the effect of apical lymph node (APN) metastasis in predicting prognosis in curatively treated node-positive rectal cancer. We also investigated the relationship between APN metastasis and the total number of metastatic lymph nodes.

Method

A retrospective study was performed of 510 curatively treated patients with node-positive rectal cancer. Clinicopathological variables, including APN status, were assessed in univariate and multivariate analyses. The prognostic significance of APN status in predicting patient outcomes and the relationship between APN status and American Joint Committee on Cancer (AJCC) N stage were analysed.

Results

At a median follow up of 47 months, the 5-year local recurrence (LR) rate, the disease-free survival (DFS) rate and the overall survival (OS) rate were 18.3%, 55.5% and 58.8%, respectively. The 5-year OS rate was 69.6% for patients with no metastasis in APNs (APN(−)) and 40.8% for patients with metastasis in APNs (APN(+)). DFS and OS for patients with undetermined APN status were between those for APN(−) and APN(+). Subgroup analysis gave a 5-year OS rate of 48.7% in Stage N1 patients with APN(+) and 58.8% for Stage N2 patients with APN(−) (P = 0.0004).

Conclusion

APN metastasis is an important prognostic factor in node-positive rectal cancer, which provides additional survival-related prognostic classification irrespective of N stage. As the APN is usually outside the radiation field, in the era of multidisciplinary treatment its assessment should be incorporated into prognostic evaluation of rectal cancer.

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