Kyung Su Han and Sang Woo Lim contributed equally to this work.
Clinicopathological characteristics of T1 colorectal cancer without background adenoma
Version of Record online: 27 FEB 2013
© 2013 The Authors Colorectal Disease © 2013 The Association of Coloproctology of Great Britain and Ireland
Volume 15, Issue 3, pages e124–e129, March 2013
How to Cite
Han, K. S., Lim, S. W., Sohn, D. K., Chang, H. J., Oh, J. H., Lee, J. H., Kim, H. R. and Kim, Y. J. (2013), Clinicopathological characteristics of T1 colorectal cancer without background adenoma. Colorectal Disease, 15: e124–e129. doi: 10.1111/codi.12102
- Issue online: 27 FEB 2013
- Version of Record online: 27 FEB 2013
- Accepted manuscript online: 8 JAN 2013 06:25AM EST
- Manuscript Accepted: 14 OCT 2012
- Manuscript Received: 17 AUG 2012
- De novo ;
- background adenoma;
- submucosal invasion;
- lymph node metastasis;
Background adenoma (BGA) is defined as benign adenomatous tissue contiguous to resected carcinomas, and the absence of BGA in a tumour is considered a histological criterion of de novo cancers. The present study aimed to identify the clinicopathological characteristics of T1 colorectal cancer (CRC) without BGA.
A retrospective review was carried out of prospectively collected data from two centres: the National Cancer Center, Korea; and Chonnam National University Hwasun Hospital, Korea. A total of 590 patients with T1 CRC, treated by endoscopic or surgical resection between January 2001 and August 2011, were enrolled. Details regarding gender, age, tumour location, endoscopic gross type, tumour size, depth of submucosal (SM) invasion, angiolymphatic invasion, tumour grade, budding and lymph node (LN) metastasis were evaluated with regard to the presence or absence of BGA.
BGA was absent in 197 (33.4%) patients. Tumour size <20 mm, flat or depressed type, deep SM depth and tumour budding were associated with the absence of BGA in univariate and multivariate analyses (P < 0.05). In surgically resected patients, LN metastases were significantly associated with the absence of BGA (P = 0.022).
T1 CRC without BGA presented several characteristics of small size (<20 mm), flat or depressed type, deep SM depth (SM 2/3), LN metastasis and tumour budding. These results indicate that de novo cancers may have a more invasive potential.