Small animal positron emission tomography imaging and in vivo studies of atherosclerosis

Authors

  • Anne Mette Fisker Hag,

    Corresponding author
    • Cluster for Molecular Imaging, Faculty of Health and Medical Sciences, Department of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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  • Rasmus Sejersten Ripa,

    1. Cluster for Molecular Imaging, Faculty of Health and Medical Sciences, Department of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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  • Sune Folke Pedersen,

    1. Cluster for Molecular Imaging, Faculty of Health and Medical Sciences, Department of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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  • Rasmus Poul Bodholdt,

    1. Cluster for Molecular Imaging, Faculty of Health and Medical Sciences, Department of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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  • Andreas Kjaer

    1. Cluster for Molecular Imaging, Faculty of Health and Medical Sciences, Department of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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Correspondence

Anne Mette Fisker Hag, Blegdamsvej 3, Building 12·3·6, DK-2200 Copenhagen N, Denmark

E-mail: annemf@sund.ku.dk

Summary

Atherosclerosis is a growing health challenge globally, and despite our knowledge of the disease has increased over the last couple of decades, many unanswered questions remain. As molecular imaging can be used to visualize, characterize and measure biological processes at the molecular and cellular levels in living systems, this technology represents an opportunity to investigate some of these questions in vivo. In addition, molecular imaging may be translated into clinical use and eventually pave the way for more personalized treatment regimes in patients. Here, we review the current knowledge obtained from in vivo positron emission tomography studies of atherosclerosis performed in small animals.

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