Does Cognitive Behavioral Therapy or Graded Exercise Therapy Reduce Disability in Chronic Fatigue Syndrome Patients? Objective Measures Are Necessary


Address correspondence to Andrew James Kewley, Unit 49, Flinders University, 401 Anzac Highway, Camden Park, SA 5038, Australia. E-mail:


Clinical trials of cognitive behavioral therapy and graded exercise therapy have consistently demonstrated improvement in self-reported quality of life and improvement of symptoms. However, due to the nature of these therapies, it is not possible to carry out a double-blinded trial design or fully control for reporting biases. Therefore, to make strong claims about efficacy and reductions in disability, objective methods should be used such as neuropsychological testing, actigraphy, and repeat exercise testing.