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Can platelet indices predict obstruction level of pulmonary vascular bed in patients with acute pulmonary embolism?

Authors


  • Authorship and contributorship

    E.G. designed, analysed the data and write the manuscript; S.S.U. retrospectively collected the data of the participants and critically revised the manuscript; E.K. and E.U. had a role in the measurement of tomographic index; B.H. retrospectively collected the data of the participants and literature review; K.T. retrospectively collected the data of the participants; G.O. collected and evaluated echocardiographic data of patients; T.K. analysed and determined blood samples results of subjects; M.U. had a role in design, analysis and interpretation of data, critical revision and final version of the manuscript.

  • Ethics

    The study protocol was approved by the Local Ethics Committee of Afyon Kocatepe University, School of Medicine, Afyonkarahisar, Turkey

  • Conflict of interest

    The authors have stated explicitly that there are no conflicts of interest in connection with this article.

  • Key messages

    In the present study, the mean value of mean platelet volume (MPV), platelet distribution width (PDW) levels, platelet counts and red cell distribution width levels were higher in pulmonary embolism (PE) groups than in control subjects (P < 0.05). There were statistically significant differences in terms of hospital length of stay (HLS), mean value of MPV, computed tomography pulmonary arterial obstruction index ratio (CTPAOIR) and systolic pulmonary arterial pressure (sPAP) in addition to systolic arterial pressure between massive and submassive PE patients (P < 0.05 for all). CTPAOIR was positively correlated with HLS, clinical probability scores, D-Dimer level, MPV, PDW levels and sPAP. These results suggest that platelet indices, MPV and PDW, can be used for the determination of disease severity, and considering therapeutic strategies for pulmonary embolism patients. 

Abstract

Introduction

Computed tomography pulmonary arterial obstruction index ratio (CTPAOIR) is related with the severity of pulmonary embolism (PE). Platelet indices including mean platelet volume (MPV), platelet distribution width (PDW) are reported to be increased in acute PE.

Objective

In this study, we aimed to evaluate the relationship between CTPAOIR and platelet indices and the utility of these parameters in the determination of PE severity.

Materials and Methods

We retrospectively analysed the demographic data, clinical probability scores, laboratory data and echocardiographic findings of 63 acute PE patients who were diagnosed by pulmonary arterial computed tomography angiography.

Results

The hospital records of 38 (60.3%) male and 25 (39.7%) female patients with acute PE and 29 (58%) male and 21 (42%) female healthy control were evaluated (P = 0.803). The mean value of MPV, PDW levels, platelet counts and red cell distribution width levels were higher in PE groups than in control subjects (P < 0.05). Massive PE was present in 33.3% of PE patients. There were statistically significant differences in terms of hospital length of stay (HLS), mean value of MPV, CTPAOIR and systolic pulmonary arterial pressure (sPAP) in addition to systolic arterial pressure between massive and submassive PE patients (P < 0.05 for all). CTPAOIR was positively correlated with HLS, clinical probability scores, D-Dimer level, MPV, PDW levels and sPAP.

Conclusion

Platelet indices, MPV and PDW, can be used for the determination of disease severity, and lead to therapeutic strategies for PE patients.

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