Elevation of serum procalcitonin in patients after chemical pleurodesis with intrapleural injection of OK-432
Authorship and contributorship
Dr Bing-ling Xu and Dr Jin-quan Yu contributed equally to this work.
The study was approved by the Institutional Review Board of the 1st affiliated hospital of Sun Yat-sen University. The requirement for a signed informed consent form was waived by the Institutional Review Board because of the retrospective nature of the study.
Conflicts of Interest
The authors have stated explicitly that there are no conflicts of interest in connection with this article.
In patients with refractory pleural effusion or pneumothorax, fever and elevated level of white blood cell count (WBC) are frequently observed after chemical pleurodesis with intrapleural injection of OK-432, which make it difficult to differentiate whether it was from the side effects of OK-432 or concurrent bacterial infection.
Procalcitonin (PCT) levels were measured before and after pleurodesis so as to discuss whether PCT is useful for distinguishing between the side effects of OK-432 and concurrent bacterial infection.
Twenty-six patients with refractory pleural effusion or pneumothorax who underwent chemical pleurodesis with intrapleural injection of OK-432 at the First Affiliated Hospital of Sun Yat-sen University between August 2010 and August 2012 were included in our study. Levels of PCT and WBC were measured before and after pleurodesis.
Of all 26 patients, 22 patients were with refractory pleural effusion, and the other four were with pneumothorax. The median serum levels of PCT and WBC elevated from 0.155 to 1.470 ng/mL (P = 0.009) and from 5.920 to 10.475 × 109/L (P = 0.000), respectively. No patient was given antibiotics and fever subsided.
Intrapleural injection of OK-432 could increase the serum level of PCT and WBC with no bacterial infection. The serum PCT level may not be useful to distinguish whether fever was caused by the side effects of OK-432 or concurrent bacterial infection.