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Spirometric reference values for healthy nonsmoking Saudi adults

Authors


  • Authorship and contributorship

    Mohammed O. Al Ghobain: principal investigator, study design, supervising the study, and writing the manuscript and journal submission; Esam Alhamad: study design, data collection and supervising the study at her center; Hassan S. Alorainy: training the technicians, study design, quality assurance, data analysis; Manal Al Hazmi: study design, data collection and supervising the study at his center; Mohamed S. Al Moamary: study design, data collection and writing the manuscript; Mohamed S. AL-Hajjaj: study design, data collection and writing the manuscript; Majdy Idress: study design, data collection and supervising the study at his center; Hamdan Al Jahdali: study design, data collection and supervising the study at his center; Mohammed Zaitoni: study design, data collection and supervising the study at his center.

  • Ethics

    The study was approved by the ethics committee of involved hospitals.

  • Conflict of interest

    The authors have stated explicitly that there are no conflicts of interest in connection with this article.

  • Support

    Funding from King Abdulaziz City for Science and Technology.

Abstract

Objectives

To derive prediction equations of spirometric values of healthy Saudi adults and to compare the derived equations with equations reported in selected population.

Methods

Cross-sectional study of healthy nonsmoking men and women Saudi adults. The measured spirometric values were the forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), peak expiratory flow (PEF) and forced mid-expiratory flow (FEF 25%–75%).

Results

A total of 621 spirometric tests were done. The prediction equations were derived using the following formula: Predicted spirometric value = constant + (b1 × age) + (b2 × height (cm)), where b1 and b2 represent the regression coefficients for age and height, respectively.

VariableConstantAge (years)Height (cm)VariableConstantAge (years)Height (cm)
Males (n = 292)   Females (n = 175)   
FVC−2.933−0.0180.046FVC−3.470−0.0160.045
FEV1−1.886−0.0190.036FEV1−2.482−0.0180.036
FEV1/FVC (%)98.41−0.095−0.068FEV1/FVC (%)100.67−0.142−0.072
PEF17.274−1.2433.471PEF−226.648−0.4994.076
FEF25%–75%0.100−0.0240.027FEF25%−75%−1.337−0.0210.031

The means of the measured FVC and FEV1 were significantly lower than the predicted values derived by the American equations of −7.2% and −4.6% among males, respectively (P value < 0.00001), and −4.7%, and −5.26% among females, respectively (P value < 0.00001).

Conclusion

The reference spirometric values derived in our study were significantly lower than the predicted values derived by the American equations.

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