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Histogenesis of pulmonary sclerosing hemangioma and significance of P63 expression

Authors

  • Jiayu Zhang,

    1. Department of Geriatrics, Huadong Sanatorium, Wuxi, Jiangsu, China
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  • Jian Wang

    Corresponding author
    1. Department of Endocrine, Nanjing General Hospital of Nanjing Military Command, Nanjing, Jiangsu, China
    • Correspondence

      Dr. Jian Wang, Department of Endocrine, Nanjing General Hospital of Nanjing Military Command, Nanjing, Jiangsu, China 221000

      Tel: +86 25 86543286

      Fax: +86 25 61576190

      email: zc8301@126.com

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  • Authorship and contributorship

    Jiayu Zhang contributed in the paper design and writing and Jian Wang in the paper design.

  • Conflict of interest

    No conflict of interest.

Abstrsct

Objective

To investigation of the histogenesis and the significance of expression of P63 in pulmonary sclerosing hemangioma (SH).

Methods

Eighteen cases of SH were retrospectively studied, and P63, surfactant protein B (SPB), thyroid transcription factor-1 (TTF-1), epithelial membrane antigen (EMA), cytokeratin (CKpan), vimentin, SMA, chromagranin (CgA), Syn and CD34 were immunohistochemically labelled with EnVision method.

Results

There are mainly four types of structures in SH tissue: solid, papillary, angiomatous (haemorrhagic), and sclerotic pattern. The tumour cells are composed mainly of two types of cells: cuboidal tumour cells and polygonal cells. The immunohistochemistry showed that cuboidal tumour cells expressed P63 (+++) in 16 cases of SH (16/18 cases). Polygonal cells and cuboidal cells of all cases express both TTF-1 and EMA at the same time (18/18 cases); cuboidal tumour cells express SPB (18/18 cases); polygonal tumour cells express vimentin (18/18 cases). In one case, a polygonal tumour cell weakly expressed Chromogranin (CgA) and Syn.

Conclusion

The P63 positive cuboidal tumour cells may be pluripotent original respiratory epithelial cells, with multidirectional differentiation capacity. Immunohistochemically labelling of P63 may have important value for SH diagnosis.

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