Increased plasma osteopontin in frequent exacerbator and acute exacerbation of COPD

Authors

  • Seung Jun Lee,

    1. Division Pulmonology and Allergy, Department of Internal Medicine, College of Medicine, Gyeongsang National University, Jinju, Korea
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  • Sung Hwan Kim,

    1. Department of Thoracic and Cardiovascular Surgery, College of Medicine, Gyeongsang National University, Jinju, Korea
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  • Wanchul Kim,

    1. Division Pulmonology and Allergy, Department of Internal Medicine, College of Medicine, Gyeongsang National University, Jinju, Korea
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  • Sujin Lim,

    1. Division Pulmonology and Allergy, Department of Internal Medicine, College of Medicine, Gyeongsang National University, Jinju, Korea
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  • Seung Hun Lee,

    1. Division Pulmonology and Allergy, Department of Internal Medicine, College of Medicine, Gyeongsang National University, Jinju, Korea
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  • Yu Eun Kim,

    1. Division Pulmonology and Allergy, Department of Internal Medicine, College of Medicine, Gyeongsang National University, Jinju, Korea
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  • Yu Ji Cho,

    1. Division Pulmonology and Allergy, Department of Internal Medicine, College of Medicine, Gyeongsang National University, Jinju, Korea
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  • Yi Yeong Jeong,

    1. Division Pulmonology and Allergy, Department of Internal Medicine, College of Medicine, Gyeongsang National University, Jinju, Korea
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  • Ho Cheol Kim,

    1. Division Pulmonology and Allergy, Department of Internal Medicine, College of Medicine, Gyeongsang National University, Jinju, Korea
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  • Jong Deog Lee,

    Corresponding author
    1. Division Pulmonology and Allergy, Department of Internal Medicine, College of Medicine, Gyeongsang National University, Jinju, Korea
    • Correspondence

      Jong Deog Lee, PhD MD, Division of Pulmonology and Allergy, Department of Internal Medicine, School of Medicine, Gyeongsang National University, 92 Chilam-dong, 660-751 Jinju, Gyeongnam, Korea.

      Tel: +82 55 750 8611

      Fax: +82 55 758 9122

      email: ljd8611@nate.com

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  • Young Sil Hwang

    1. Division Pulmonology and Allergy, Department of Internal Medicine, College of Medicine, Gyeongsang National University, Jinju, Korea
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  • Authorship and contributorship

    J.D. Lee and S.J. Lee are guarantors of the manuscript.

  • J.D. Lee contributed as the corresponding author, reviewing all data and revising the manuscript. S.J. Lee contributed as the primary author, reviewing all data and writing the manuscript. S.H. Kim contributed to the preparation of the manuscript, and read and approved the final manuscript. W. Kim contributed to the preparation of the manuscript, and read and approved the final manuscript. S. Lim contributed to the preparation of the manuscript, and read and approved the final manuscript. S.H. Lee contributed to the preparation of the manuscript, and read and approved the final manuscript. Y.E. Kim contributed to the preparation of the manuscript, and read and approved the final manuscript. Y.J. Cho contributed to the preparation of themanuscript, and read and approved the final manuscript. Y.Y. Jeong contributed to the preparation of the manuscript, and read and approved the final manuscript. H.C. Kim contributed to the preparation of the manuscript, and read and approved the final manuscript. Y.S. Hwang contributed to the preparation of the manuscript, and read and approved the final manuscript.
  • Conflict of interest

    The authors have stated explicitly that there are no conflicts of interest in connection with this article.

Abstract

Introduction

Osteopontin (OPN) is a phosphorylated glycoprotein expressed by diverse tissues including bone, brain, kidney, liver and lung. Limited data exist regarding OPN in chronic obstructive pulmonary disease (COPD) and the exacerbation of this condition.

Objectives

The aim of this study was to evaluate plasma OPN levels and investigate the clinical usefulness of plasma OPN measurement in patients with COPD.

Methods

Plasma OPN levels were measured and compared in patients with COPD exacerbation (n = 64), patients with stable COPD (n = 68) and healthy controls (n = 30). In patients with COPD exacerbation, plasma OPN levels were measured repeatedly in convalescence. Patients with stable COPD were categorized into frequent and infrequent exacerbators according to their frequency of exacerbation, and plasma OPN levels were compared between these two groups. Plasma OPN levels were determined by enzyme-linked immunosorbent assay.

Results

Patients with COPD exacerbation had increased plasma OPN levels compared with those with stable COPD and healthy controls (32.6 ± 29.6, 17.6 ± 11.1, 8.4 ± 6.1 ng/mL, respectively; P < 0.001). In patients with COPD exacerbation, plasma OPN levels were significantly decreased in convalescence (44.8 ± 43.5 vs 24.6 ± 13.6 ng/mL; P = 0.034). Frequent exacerbators had higher plasma OPN levels compared with infrequent exacerbators (22.5 ± 12.0 vs 15.0 ± 9.8 ng/mL; P = 0.008).

Conclusions

Plasma OPN levels were increased in patients with COPD exacerbation and frequent exacerbators, which suggests a possible role for OPN as a biomarker of COPD exacerbation.

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